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Rucaparib, the PARP inhibitor approved for the treatment of ovarian cancer, may have potential clinical benefit for patients with advanced pancreatic cancer and a BRCA1/2 mutation.

Clues to cancer treatments are buried in inaccessible patient records; the Virginia Senate reconvenes Tuesday to discuss a budget plan proposed by Republican leaders that expands Medicaid; California introduces a Senate bill to offer full health coverage to undocumented adults.

Trial results show that patients with hemophilia A with or without factor VIII inhibitors treated with emicizumab-kxwh every 4 weeks can have clinically meaningful control of bleeding.

The health hazards of workplace wellness programs fall within 6 categories.

The second study in less than a week regarding youth and suicide was released Monday, with the latest one showing an age-related trend in racial disparities in suicide rates in elementary and middle school-aged children. The study, published in JAMA Pediatrics, showed that suicide rates for black children aged 5-12 were roughly 2 times higher than those of similarly-aged white children.

The FDA has warned of serious cases of neural tube birth defects involving the brain, spine, and spinal cord affecting babies born to women with HIV being treated with dolutegravir.

President Donald Trump named Robert Wilkie, a veteran GOP aide and acting secretary of the Veterans Affairs (VA), to lead the VA; with the power of a pen, HHS Secretary Alex Azar is eager to play the role of a “joyful regulator;” patients with amyotrophic lateral sclerosis (ALS) are finding they are caught between hope, expectations, and insurers that won’t pay for a $145,000 intravenous drug.

Neck pain associated with migraine cannot be attributed to increased trapezius activity during rest, mental stress, and physical activity or prolonged muscle activity and should be seen as an accompanying symptom of migraine.

Harvard healthcare economist Michael E. Chernew, PhD, who is co-editor in chief of The American Journal of Managed Care®, discusses elements of the Trump administration proposal to control drug prices.

The study comes as FDA is moving to bring more order to the area of mobile health. It is in the midst of a pilot for a precertifcation process that involves well-known companies such as Apple, Verily, and diabetes-specific companies like Tidepool.

Mines that are in compliance with the Mine Safety and Health Administration's requirements experience significantly lower lung disease cases over time compared with mines not in compliance. However, the lung disease burden among the coal mining industry has increased in the last decade.

Approximately 20% of patients with epilepsy have a co-occurring autoimmune disorder, and autoantibodies directed against the smaller isoform of glutamate decarboxylase (GAD65Ab) have been found in patients with epilepsy, as well as in patients with stiff person syndrome and type 1 diabetes.

A study found the use of interprofessional education improves students' knowledge and skill sets and promotes collaborative behaviors.

Terry Kohl, a real estate agent in New Jersey, battled what she thought was indigestion for 6 months and went repeatedly to a gastroenterologist for what she thought was a case of “grumbly gut.” Her "indigestion" led to a coronary artery bypass surgery soon after a trip to Rome left her breathless. Read about how women experience health and healthcare differently as National Women's Health Week draws to a close.

A phase III randomized trial, with results being presented in June at the American Society of Clinical Oncology Annual Meeting, found the addition of nelarabine to standard chemotherapy regimen in patients with T-cell malignancies can improve disease-free survival rates.

The FDA has approved an expanded indication for Gilead Science’s emtricitabine/tenofovir disoproxil fumarate (Truvada) to reduce the risk of HIV in at-risk adolescents. Truvada for pre-exposure prophylaxis (PrEP) was first approved for the use in adults in 2012.

This week, the top managed care stories included President Donald Trump's plan to drive down drug prices; the FDA approved the first biosimilar of the year; a study found rapid uptake of PD-1 agents after FDA approval.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

Overcoming the challenges to a holistic approach to opioid recovery is critical to engaging patients safely and comfortably, and to supporting sustained recovery. Here are 5 elements that contribute to a successful integrated approach.

FDA Commissioner Scott Gottlieb, MD, expressed concerns about a version of a "right-to-try” bill in the House of Representatives; the Trump administration Friday is set to reinstate rules prohibiting clinics that receive federal funding from providing abortions or referring patients to places that do; the National Institutes of Health has frozen a highly criticized, $100 million, 10-year study of moderate drinking backed by the alcoholic beverage industry.

The FDA has approved Amgen and Novartis’ erenumab-aooe, marking the first approved calcitonin gene-related peptide (CGRP) inhibitor for the prevention of migraine in adults. The treatment will cost 30% less than expected.

Deprivation in patients with chronic obstructive pulmonary disease (COPD) is associated with increased emergency healthcare use, healthcare costs, and mortality rates, according to research.

An analysis from the Kaiser Family Foundation of the 2017 financial performance of health insurers found that last year was their best year selling individual-market health insurance since the Affordable Care Act was put into place, even without the cost-sharing subsidies that they lost in the fourth quarter.

The number of Medicare Part D enrollees reaching catastrophic coverage increased by more than 50% from 2013 to 2016, according to an analysis form Avalere Health

Completion of the recommended 3 doses of the human papillomavirus (HPV) vaccine showed differences between sexes, with fewer girls and women finishing the series within 1 year as compared to boys and men, according to a new study published in the American Journal of Public Health.

CMS has approved a 5-year extension of Maryland’s all-payer model, expanding the approach across the health system starting January 1, 2019.

Organizers of the project said it aims to build a better set of data on hypoglycemia that will help researchers and clinicians understand the condition, predict it, and gauge its cost.

While immune checkpoint inhibitors significantly improve overall survival in both sexes, the magnitude of benefit is dependent on sex, according to new study findings.

A new law in Vermont would allow the state to import drugs from Canada, but it needs to be certified by HHS; the House passes a bill to expand veterans' access to private care; the FDA has approved the first nonopioid to treat opioid withdrawal symptoms.

Chronic migraine is associated with pain, psychiatric, and endocrine/neurological comorbidities, as well as sleep disorders.