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A recent study reports that monocytes from patients with myeloproliferative neoplasms (MPNs) have a defective negative regulation of Toll-like receptor (TLR) signaling that allows for the unrestrained production of tumor necrosis factor alpha after TLR activation. Additionally, the authors write that TLR signaling not only contributes to chronic inflammation in patients with MPN, but also may predispose individuals to acquire MPNs.

Federal contractors lost not only wages during the 5-week government shutdown, some of them also lost health insurance; with advances in gene therapy, scientists are beginning to talk about a cure in sickle cell disease; there’s bipartisan interest in attacking the issue of unexpected medical bills, and the effort has been aided by President Donald Trump, who voiced support last week for protecting patients.

Nonheadache and headache specialists have moderate levels of agreement in classifying common chronic headache disorders after using the telephone classification interview model, according to a study.

A new study examined what factors might prolong time from onset of symptoms to diagnosis of multiple sclerosis.

A phase 4 study of formoterol fumarate showed similar safety performance as placebo in patients with moderate-to-severe chronic obstructive pulmonary disease, according to a recently published study.

The study counted all kinds of activity, including walking to work, repairs around the house, and, of course, sports.

A study of 3 assessments for patients with chronic lymphocytic leukemia treated with fludarabine, cyclophosphamide, and rituximab are examined.

A recent study sought to determine the relationship between occupational stress and obesity. The study authors investigated if baseline and prolonged exposure to high job demands were associated with major weight gain.

Two recent studies analyzed patients with multiple myeloma to identify factors that impacted response to therapy.

Teen nicotine use drastically increased in 2018, largely due to the popularity of e-cigarette products. The FDA has taken a number of recent steps to address the epidemic that has been said to have created a new generation of nicotine addicts. Here are 5 of the latest updates and actions in the fight against teen vaping.

Examining the frequency of bloodstream infection in these patients, researchers have found that staphylococcus aureus is most prevalent, followed by Klebsiella and E. coli.

Men living with HIV are more likely to develop lung disease from long-term marijuana smoking compared with uninfected men.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

Presumed 2020 presidential candidates are trying to stake a claim to one of healthcare’s main concerns—surging prescription drug prices; enrollment in Idaho's health insurance exchange is expected to drop by 20% due to Medicaid expansion; employer groups can help overcome barriers, such as patient fears and misinformation, and create confidence about using biosimilars.

Panelists at the World Economic Forum Annual Meeting in Davos, Switzerland, discussed the importance of addressing mental health, the role stigma plays, and next steps once the conversation opens up.

https://www.pharmacytimes.org/on-demand/examining-hyperhidrosis-excessive-sweating-a-managed-markets-update-on-new-treatments-featuring-a-patient-perspective

This week, the top managed care news included the Institute for Clinical and Economic Review investigating rising drug prices; CMS expanding value-based insurance design; and researchers using a blood test to detect preclinical Alzheimer disease.

High drug prices have long been a burden on the US healthcare system, and recent weeks have seen a burst of Congressional activity aimed at driving down rising drug costs. But is Congress all talk and no action on this key issue?

The first and only test authorized by the FDA to detect and monitor minimal residual disease (MRD) in multiple myeloma (MM) and B-cell acute lymphoblastic leukemia (ALL) has received coverage for Medicare patients.

The partnership will seek repeatable, scalable models to present at a summit later this year.

What do Americans think about Medicare for All or other ways to allow people to have health insurance if coverage does not come through work? This week, the Kaiser Family Foundation released results of a poll about the issue, while a coalition of healthcare industry players released a digital ad arguing against a single-payer option.

Patients with mitochondrial disease have a significantly higher cost burden compared with the general population, according to the results of a recent retrospective claims analysis.

The uninsured rate in the United States rose to a 4-year high of 13.7% in the fourth quarter of 2018; President Trump has instructed administration officials to tackle surprise medical billing; and a measles outbreak has hit Washington State.

Among people with obesity, those with migraine have greater total healthcare utilization and expenses compared with those without migraine.

According to a new study, requiring drug price disclosures in television ads could significantly influence consumer thinking and behavior, especially for expensive drugs.

Healthcare across the globe is at a moment of change. During the World Economic Forum Annual Meeting in Davos, Switzerland, a panel of experts discussed the transformation taking place in healthcare and the tough questions ahead that still need to be answered.

https://www.pharmacytimes.org/on-demand/managed-care-considerations-in-meeting-the-complex-needs-of-patients-with-pancreatic-cancer

Seeking to generate data for the development and validation of clinical decision rules in pediatric febrile neutropenia (FN), researchers used 2 decades of data on FN episodes in pediatric patients.

Between 2012 and 2016, insulin costs for patients nearly doubled while utilization remained flat; the pharmaceutical industry's lead lobbying group spent a record amount in 2018; and alcohol-associated liver disease has surpassed hepatitis C as the top cause of liver transplants.

Prompt diagnosis and timely intervention is key in improving outcomes for patients with multiple sclerosis (MS). A new study in Multiple Sclerosis Journal outlines quality standards for timely, brain health–focused MS care.