Publication|Articles|December 4, 2025

2025 Year in Review: Lymphoma

2025 Year in Review: Lymphoma

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Key Takeaways

Combination therapies in lymphoma, including bispecific antibodies and antibody-drug conjugates, have shown significant advancements in 2025.
EPCORE NHL-2 trial reported an 87% response rate in relapsed/refractory diffuse large B-cell lymphoma with epcoritamab plus chemoimmunotherapy.
FDA approved the epcoritamab plus R2 regimen for second-line follicular lymphoma, marking a significant milestone.
Full data from the EPCORE FL-1 trial will be presented at the American Society of Hematology meeting in December 2025.

Combination therapy in lymphoma continued to make news in 2025, whether built around bispecific antibodies, notably epcoritamab (Epkinly), or antibody drug conjugates, such as polatuzumab vedotin (Polivy). Data from EPCORE NHL-2 in diffuse large B-cell lymphoma (DLBCL) made news at the European Hematology Association 2025 Congress, showing that epcoritamab plus chemoimmunotherapy brought an 87% response rate in R/R DLBCL. The big news came November 18, when the FDA approved the epcoritamab plus R² regimen (rituxan plus lenalidomide) in second-line follicular lymphoma. Full data for the EPCORE FL-1 trial will be presented at the American Society of Hematology in December 2025.

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