Publication
Article
The American Journal of Managed Care
Author(s):
This study examines the impact of the Affordable Care Act (ACA) on substance-associated emergency department (ED) visits among young adults, revealing reduced alcohol-associated visits but unchanged opioid-associated visits.
ABSTRACT
Objectives: The Affordable Care Act (ACA), enacted in 2010, aimed to improve health insurance coverage and access to care, notably through a provision extending dependent coverage up to age 26 years. This study investigates the ACA’s impact on substance use disorder (SUD)–associated emergency department (ED) visits among young adults aged 23 to 29 years.
Study Design: A quasi-experimental study analyzed opioid- and alcohol-associated ED visits and inpatient admissions among young adults (aged 23-25 [treatment] vs 27-29 [comparison] years) using 2007-2019 Nationwide Emergency Department Sample data.
Methods: A difference-in-differences approach assessed the ACA’s impact, adjusting for covariates including sex, comorbidities, payer source, income, residence, and hospital region. Generalized linear models estimated adjusted ORs with 95% CIs, ensuring robust analysis of the ACA’s effects on substance-related health care utilization.
Results: Opioid-associated ED visits had no change between the treatment and comparison groups, whereas alcohol-associated ED visits declined more for the treatment group after the ACA (OR, 0.841; 95% CI, 0.828-0.855). No changes in inpatient admissions among opioid- or alcohol-associated visits, respectively, were seen between the 2 groups.
Conclusions: Our findings indicate that the ACA’s implementation led to mixed effects on substance-associated health care utilization among young adults, with reduced alcohol-associated visits in the treatment group but unchanged discrepancies in opioid-associated ED visits and inpatient admissions between the 2 groups. Further research is warranted to explore state-level variations and population-level substance use trends along with continuous monitoring to inform interventions addressing substance-associated public health challenges.
Am J Manag Care. 2025;31(9):In Press
Takeaway Points
The Affordable Care Act (ACA), which was enacted in 2010, was a transformative health policy initiative aimed at expanding health insurance coverage and improving access to care in the US, particularly for young adults. One of its key provisions allowed young adults to remain on their parents’ health insurance plans until age 26 years, addressing a critical gap in coverage for this demographic.1 Prior to the ACA, the uninsured rate was approximately 29% among individuals aged 18 to 24 years and approximately 27% among those aged 25 to 34 years.2 Lack of health care access can force young adults to rely on emergency departments (EDs) for their medical needs, including behavioral health issues such as substance use disorders (SUDs), due to limited access to primary and preventive health care services.3 The intention behind extending dependent coverage was to improve access to a range of health services, including outpatient treatment for SUDs, which have become increasingly prevalent among young adults.4
Over the past 2 decades, the rise in substance use and dependence has emerged as a pressing public health concern in the US, with SUDs affecting more than 20 million Americans annually.5,6 Younger adults aged 18 to 35 years are at heightened risk for risky substance use behaviors, including opioid use, excessive alcohol consumption, and recreational drug use.7 This age group is also significantly impacted by the ongoing opioid epidemic, resulting in a dramatic increase in opioid-related ED visits, which quadrupled between 1993 and 2010.8 The consequences of SUDs extend beyond individual health, including their contribution to increased morbidity and mortality rates exemplified by the 106,000 overdose deaths recorded in 2021 and the substantial economic burden on society.6,9
Young adults with SUDs frequently utilize ED services, often as a safety net because of the barriers to accessing ambulatory care. Research indicates that individuals with SUDs utilize ED services at rates 50% to 100% higher than those without such disorders.10 The proportion of ED visits associated with mental health and substance use has risen markedly, from 4% to 6% in the early 1990s to an estimated 12% by 2007.11 Between 2009 and 2017, the number of annual ED visits related to opioids and alcohol surged from 73,262 to 1,070,747, with a notable increase among young adults aged 21 to 29 years.12,13 Some of these visits may have been preventable, including through better access to outpatient care, but numerous barriers persist, including a shortage of providers who accept public insurance, stigma, and insufficient mental health and SUD resources.14,15 The ACA’s dependent coverage extension aimed to alleviate financial barriers, yet gaps in care for SUDs remain a challenge, as highlighted by literature examining the ACA’s effects on behavioral health and substance use outcomes.14
Despite the extension improving insurance coverage, the relationship between the ACA dependent coverage provision and ED utilization for SUDs is complex and multifaceted. Although the extension may enhance financial access to care, other structural and systemic barriers persist, particularly for populations with high unmet needs.16 Such challenges complicate the task of hypothesizing the ACA’s impact on ED visits a priori, as the effects of improved insurance coverage must be considered alongside the broader health care landscape.17
Sociodemographic disparities further complicate the landscape of ED visits for SUDs. Young adults in rural areas, those without insurance, and individuals from lower-income backgrounds are more likely to seek care in EDs for substance-related issues.18 Compared with their privately insured counterparts, Medicaid and uninsured patients tend to visit EDs more frequently for chronic conditions, mental health disorders, and SUDs.19 In 2017, more than 10.7 million ED visits were recorded for mental health or substance use issues, predominantly among middle-aged adults with low socioeconomic status.12,20,21 Although the ACA’s dependent coverage extension has been associated with improved access to care, the impact on substance use–related ED visits among young adults remains underexplored.
Study findings have shown that the ACA’s Medicaid expansion significantly reduced all-cause mortality, including deaths related to SUDs.22 However, research examining the effects of the dependent coverage provision on the highest-risk age group for SUDs (21-29 years) is limited. This gap in the literature raises questions about the complexities of access to care for young adults with SUDs, particularly in light of persistent barriers such as provider shortages and insurance limitations.14,15 Understanding how the ACA provision influences utilization of emergency services for young adult substance use is critical. Using the Nationwide Emergency Department Sample (NEDS), this study aimed to characterize the impact of the ACA dependent coverage extension on ED use among young adults (aged 23-29 years) for (1) alcohol use and (2) opioid use. Results of this analysis have important implications for health policy and practice.
METHODS
Study Design and Data
NEDS, a deidentified data set, represents 20% of all US ED visits.23 NEDS data are collected annually; this analysis used the 2007, 2009, 2011, 2013, 2015, 2018, and 2019 data. This quasi-experimental study included an intervention group (aged 23-25 years) and a comparison group (aged 27-29 years). Those aged 26 years were excluded per prior research2 due to classification challenges. Opioid- and alcohol-associated ED visits were compared pre-ACA (2007-2009) and post ACA (2011-2019) because of their high prevalence and sensitivity to ACA-driven changes in access to care. Other substances were excluded due to lower prevalence and limited policy impact evidence. Of 19,856,756 total ED visits included in analyses, 164,929 were opioid associated and 285,578 were alcohol associated. The University of Nevada, Las Vegas Institutional Review Board deemed the study exempt due to the data set’s deidentified, public nature.
Measures
Four binary dependent variables investigated in this study were ED visits associated with use of opioids and alcohol, respectively, and admission to inpatient care after the opioid- or alcohol-associated ED visit.24 We utilized both principal and secondary diagnoses of opioid- and alcohol-associated ED visits in patients aged 23 to 25 years and 27 to 29 years using the International Classification of Diseases, Ninth and Tenth Revisions, Clinical Modification.25,26 Admission to inpatient care can indicate ED visits with relatively severe clinical conditions as opposed to ED visits that were unnecessary or for ambulatory care–sensitive conditions.27,28
The ACA and treatment were the 2 independent variables of interest. The ACA was a dichotomous variable, with 0 indicating pre–ACA implementation (2007-2009) and 1 indicating post ACA implementation (2011-2019). Treatment was a dichotomous variable, with 1 indicating the treatment group (aged 23-25 years; those affected by the ACA dependent coverage extension) and 0 indicating the comparison group (aged 27-29 years; those not affected by the ACA dependent coverage extension), consistent with previous research.2 The control variables or covariates in multivariable analyses included sex (female, male [reference]), the number of diagnoses (comorbidities), payer source (Medicaid, uninsured, private insurance [reference]),29 median income by zip code in quartiles (0-25th percentile, 26th-50th percentile, 51st-75th percentile, 76th-100th percentile [reference]),30 patient residence location (rural [ie, not metropolitan or micropolitan counties], nonrural [reference]),31 and US region of hospital location (Northeast, Midwest, South, West [reference]).32
Statistical Analysis
A difference-in-differences (DID) analysis was conducted to examine impacts of the ACA dependent coverage extension on substance use–associated ED visits, controlling for covariates. We included the covariates listed earlier in the DID analysis and adjusted for potential differences in observed characteristics between the treatment (aged 23-25 years) and comparison (aged 27-29 years) groups that could introduce bias in estimating ED utilization trends. These covariates were selected to control for systematic differences between groups that could influence health care access, health status, and substance use behaviors. Although a well-balanced DID design does not theoretically require covariate adjustment if the parallel trends assumption holds, the inclusion of covariates serves as a robustness measure to mitigate residual confounding and enhance the validity of the findings. The DID assumption of the parallel trends was tested before the analysis. First, we used data on the outcomes from both treatment and comparison groups before the ACA was implemented. Second, we tested whether the trends in outcomes leading up to the ACA statistically differed between the treatment and comparison groups33 by restricting our attention to the prior ACA data and then examining the interaction between the number of years before ACA and the treatment variable on the dependent variables; this yielded insignificant regression coefficients of the interaction term, with P values of .4635 for opioid use, .7906 for alcohol use, .0593 for inpatient admissions among opioid users, and .6491 for inpatient admissions for alcohol users.
The DID estimator (δ) is:
δ = (Ytreatment post – Ytreatment pre) – (Ycomparison post – Ycomparison pre),
where δ represents effect of the ACA on the average outcome of Y, Y shows average outcomes, treatment represents a group (aged 23-25 years) exposed to ACA, comparison represents a group (aged 27-29 years) not exposed to ACA, pre represents before ACA implementation, and post represents after ACA implementation. The DID estimate is equal to 0 if there is no association between policy implementation and subsequent outcomes. In the econometric framework, for individual i in treatment group j at time t with 2 groups (treatment and comparison group) and 2 time periods (pre- and post ACA), baseline DID models of this study take the form:
Yijt = β0 + β1Postit + β2Treatij + β3(Treatij × Postit) + Xijt + εijt,
where Yijt represents an outcome variable for a dependent variable for patient i of treatment group j in time t; Postit is a dummy variable for whether a patient occurred in the post-ACA period; Treatij is a dummy variable indicating the value of 1 if a patient is in the treatment group and 0 otherwise; β3represents impact of the ACA on changes in outcomes; Xijt is a vector of fixed effects of control variables for sex, comorbidity, and median income by zip code; and εijt is the error term.
The impact of the ACA was observed as β3 of the interaction between treatment and post. A generalized linear model was selected for estimating β3. Given the fact that all discharges in a hospital were contained in the data set if the hospital was selected into the NEDS, the generalized mixed model using hospital as a random effect was eventually utilized to take into account cluster effects among discharges within each hospital. Several sensitivity analyses were conducted, including the comparison between models with and without the time (year) fixed effect and the comparison of the weighted logistic regression model against the generalized mixed model. Sensitivity analysis results were consistent in terms of the post-ACA effects on the 2 groups (shown in the eAppendix [available at ajmc.com]). Results generated from the generalized mixed model based on equation 2 are presented using adjusted ORs with 95% CIs in the Results section.
RESULTS
Table 1 presents sociodemographic characteristics of patients aged 23 to 25 years (treatment) and 27 to 29 years (comparison) who had ED visits associated with use of opioid and alcohol before and after ACA implementation. Approximately 60% of ED visitors were female, and the comparison group had a slightly higher number of diagnoses than the treatment group in both the pre- and post-ACA periods. Medicaid coverage increased and uninsurance declined in the post-ACA period for both the treatment and comparison groups, and approximately 12% of the patients resided in rural areas.
Among ED visits, 0.52% for the treatment group and 0.58% for the comparison group were associated with opioid use prior to the ACA vs rates of 0.84% and 1.02%, respectively, after ACA implementation. Furthermore, 1.87% of ED visits in the treatment group and 1.99% of ED visits in the comparison group were associated with use of alcohol prior to the ACA, whereas the rates were 1.07% and 1.39%, respectively, post ACA. In addition, among patients associated with opioid use, 38.15% in the treatment group and 40.63% in the comparison group were admitted to inpatient care before the ACA, and 27.55% and 31.27%, respectively, were admitted to inpatient care after the ACA. Among patients associated with alcohol use, 24.55% and 29.59% were admitted to inpatient care in the treatment and comparison groups, respectively, before the ACA, whereas 20.73% and 25.44%, respectively, were admitted to inpatient care after the ACA.
Table 2 presents the results of the multivariable analysis. In the pre-ACA period, compared with the control group, the treatment group was less likely to visit the ED for opioid-associated reasons (OR, 0.920; 95% CI, 0.899-0.942). Post ACA, this difference was no longer statistically significant (OR, 1.013; 95% CI, 0.987-1.039), indicating that the ACA did not differentially impact opioid-associated ED visits across age groups. However, opioid-associated ED visits increased overall post ACA (OR, 1.263; 95% CI, 1.241-1.286).
The treatment group had lower odds of alcohol-related ED visits than the control group before the ACA (OR, 0.972; 95% CI, 0.960-0.985), and this disparity further increased post ACA (OR, 0.841; 95% CI, 0.828-0.855), suggesting a more pronounced reduction in alcohol-associated ED visits among the treatment group.
Among young adults whose ED visits were associated with opioids, the odds of inpatient admission were similar between the treatment and control groups before the ACA (OR, 1.012; 95% CI, 0.958-1.068), and this pattern remained unchanged post ACA. However, the ACA was associated with lower overall odds of inpatient admission for opioid-associated ED visits (OR, 0.326; 95% CI, 0.312-0.341), suggesting a shift in hospitalization trends.
Among young adults whose ED visits were associated with alcohol, the treatment group had lower odds of inpatient admissions compared with the control group before the ACA (OR, 0.871; 95% CI, 0.843-0.899). Post ACA, this difference remained unchanged (OR, 1.010; 95% CI, 0.956-1.055), indicating that the gap between the age groups remained similar. However, the ACA was associated with lower overall odds of inpatient admission for alcohol-associated ED visits (OR, 0.298; 95% CI, 0.289-0.307), suggesting a shift in hospitalization trends. Overall, the ACA was associated with reduced odds of inpatient admission for alcohol-associated ED visits among all young adults (aged 23-29 years).
DISCUSSION
Our findings suggest mixed effects of the ACA dependent coverage extension on substance use–associated ED visits, aligning with and diverging from prior research in nuanced ways.34 The ACA’s dependent coverage provision aimed to improve young adults’ access to health care, and our results suggest that opioid-associated ED visits increased among all young adults (aged 23-29 years) following implementation, a trend that contrasts with earlier studies anticipating that expanded insurance coverage would reduce ED visits through improved access to preventive care and outpatient services.35 This increase was not specific to the treatment group, as there was no significant interaction between age group and ACA period for opioid-related visits, suggesting that broader population trends—such as increased opioid availability and use—may be driving these findings.36 Ongoing issues with the opioid epidemic, specifically fentanyl availability, may explain these findings because opioid-related deaths in the US significantly rose from 6.8 per 100,000 in 2010 to 25 per 100,000 in 2022.37 Many of these cases involve overdose events requiring emergency hospitalization, contributing to higher inpatient admissions.38
The results further suggest that the ACA dependent coverage extension had a differential effect on alcohol-associated ED visits. Before the ACA, young adults aged 23 to 25 years had significantly lower odds of an alcohol-associated ED visit than those aged 27 to 29 years. Following the ACA, this difference became more pronounced, with the treatment group showing further reductions in alcohol-associated ED visit odds relative to the comparison group. This suggests that alcohol use is influenced by social and environmental factors beyond insurance access.39 The widening disparity post ACA may indicate a beneficial effect of dependent coverage on access to behavioral health services for alcohol use among young adults. However, the overall high volume of alcohol-associated ED visits across both age groups underscores the persistent burden of problematic alcohol use among young adults, suggesting that insurance expansion alone may be insufficient to address broader population-level drinking hazards.
Prior to the ACA, the treatment group had slightly lower odds of opioid-associated ED visits than the comparison group, but this gap waned post ACA, suggesting a convergence rather than a divergence in ED utilization patterns.36 The treatment group, benefiting from dependent coverage and public health efforts, may have had improved access to care.40 Meanwhile, the control group, less likely to gain insurance, faced persistent treatment barriers, leading to ongoing opioid-associated complications requiring ED utilization.41 These findings align with research indicating that insurance expansion improves access but does not uniformly reduce substance-related ED visits.36
Opioid-associated inpatient admissions declined post ACA, suggesting that more patients presented to the ED with less severe conditions, which aligns somewhat with studies supporting utilization of earlier or outpatient-based care but contrasts with others reporting stable or increasing inpatient treatment needs.42,43 The unchanged admission rates between groups pre- and post ACA indicate a uniform impact of ACA policies on inpatient care among young adults. Medicaid expansion and dependent coverage likely contributed to the decline in opioid-associated inpatient admissions by increasing access to outpatient services.43 Before and during the early ACA years, opioid users often sought prescriptions in outpatient settings. By the mid-2010s, prescription drug monitoring programs (PDMPs) led to reduced prescribing, potentially increasing ED visits for drug-seeking and shifting users to illicitly obtaining opioids.44,45 Although our data do not directly capture patient intent or prescription-seeking behavior, this broader policy context may explain why some patients presented without conditions warranting inpatient admission.
For alcohol-related ED visits, the treatment group had lower inpatient admission odds pre-ACA, with a similar gap post ACA, despite an overall decline, which is consistent with prior research.39 The ACA likely reduced financial barriers to outpatient care, although structural and behavioral factors may still influence inpatient admissions.39 Alcohol use patterns may be more responsive to insurance expansion than opioid use because they are less entangled with illicit drug markets and criminalization pressures.Hospitals may have also adopted alternative management strategies, such as observation units and community-based treatment, reducing inpatient admissions while addressing patient needs.46 However, persistent inpatient demand underscores the need for expanded treatment access and improved care coordination.47
By expanding insurance coverage, the ACA may have reduced reliance on EDs for alcohol- and opioid-related problems by enabling more outpatient care.42 Previously, uninsured patients in states such as Nevada may have accessed treatment through involuntary holds (eg, Legal 2000). Post ACA, improved insurance coverage likely facilitated voluntary treatment, potentially reducing substance-related ED visits. Future research should examine how expanded insurance coverage interacts with structural factors, such as availability of outpatient services, stigma, and socioeconomic barriers, to influence ED utilization patterns.36 Researchers should also explore how state-level policy differences, such as Medicaid expansion timing or PDMP implementation, affected these trends.44,45,48 Additionally, investigating demographic and geographic variations could reveal important disparities in how the ACA impacted different populations.49
Limitations
These findings should be considered alongside key limitations. First, NEDS data lack patient race, ethnicity, and hospital location in certain years, potentially introducing bias and limiting geographic and demographic analyses.49 Second, although Medicaid expansion status was included in models, variations in implementation may still affect results.48 Third, state-level policy variations complicate assessments of the ACA’s impact, warranting future interrupted time series analyses. Fourth, interpreting the OR of the treatment-ACA interaction was challenging, so we focused on effect significance rather than magnitude.50 Lastly, we could not adjust for factors such as education and income due to data limitations. We also acknowledge that we could not account for all contemporaneous factors, such as the rise of fentanyl and other synthetic opioids, which may contribute to increased opioid-associated ED admissions regardless of insurance status. Despite these constraints, the use of a comparison group and pre-post design strengthens our analysis.
CONCLUSIONS
Although the ACA’s dependent coverage provision did not differentially impact opioid-associated ED visits between the treatment and comparison groups, our findings indicate a greater reduction in alcohol-associated ED visits among young adults newly eligible for coverage (aged 23-25 years) compared with their slightly older peers. This age-specific decline in alcohol-associated ED use may reflect improved access to preventive or behavioral health services among insured young adults or shifting patterns in substance use behaviors in response to increased engagement with the health care system. These findings suggest that even modest expansions in coverage can yield important behavioral health benefits, particularly for substances such as alcohol that are often underrecognized in acute care settings. Future research should explore mechanisms driving this reduction—such as increased outpatient service utilization, earlier intervention for alcohol misuse, or changing perceptions of risk—and assess whether similar patterns emerge for other substance types or under subsequent health policy reforms.
Author Affiliations: Department of Social and Behavioral Health (RRS, TG), Department of Healthcare Administration and Policy (CC), and Center for Health Disparities Research (JJS), School of Public Health, University of Nevada, Las Vegas, Las Vegas, NV.
Source of Funding: None.
Author Disclosures: The authors report no relationship or financial interest with any entity that would pose a conflict of interest with the subject matter of this article.
Authorship Information: Concept and design (RRS, JJS); acquisition of data (CC, JJS); analysis and interpretation of data (RRS, TG, JJS); drafting of the manuscript (RRS); critical revision of the manuscript for important intellectual content (TG, CC, JJS); statistical analysis (JJS); administrative, technical, or logistic support (TG, CC, JJS); and supervision (JJS).
Address Correspondence to: Jay J. Shen, PhD, University of Nevada, Las Vegas, 4700 S Maryland Pkwy, Las Vegas, NV 89154. Email: jay.shen@unlv.edu.
REFERENCES
1. Cantor J, Monheit A, DeLia D, Lloyd K. The role of federal and state dependent coverage eligibility policies on the health insurance status of young adults. National Bureau of Economic Research working paper 18251. July 2012. doi:10.3386/w18254
2. Barbaresco S, Courtemanche CJ, Qi Y. Impacts of the Affordable Care Act dependent coverage provision on health-related outcomes of young adults. J Health Econ. 2015;40:54-68. doi:10.1016/j.jhealeco.2014.12.004
3. Fortuna RJ, Robbins BW, Mani N, Halterman JS. Dependence on emergency care among young adults in the United States. J Gen Intern Med. 2010;25(7):663-669. doi:10.1007/s11606-010-1313-1
4. Lu W, Lopez-Castro T, Vu T. Population-based examination of substance use disorders and treatment use among US young adults in the National Survey on Drug Use and Health, 2011–2019. Drug Alcohol Depend Rep. 2023;8:100181. doi:10.1016/j.dadr.2023.100181
5. De Leon J, Moonie S, Shen JJ, Gutierrez KS, Cross CL. Opioid-related hospitalizations and intravenous drug users: socio-demographic, spatial, and comorbid associations among hospital inpatients and community-based harm reduction organization participants. J Opioid Manag. 2021;17(3):195-205. doi:10.5055/jom.2021.0630
6. Wani RJ, Wisdom JP, Wilson FA. Emergency department utilization for substance use-related disorders and assessment of treatment facilities in New York state, 2011-2013. Subst Use Misuse. 2019;54(3):482-494. doi:10.1080/10826084.2018.1517801
7. Richmond-Rakerd LS, Slutske WS, Wood PK. Age of initiation and substance use progression: a multivariate latent growth analysis. Psychol Addict Behav. 2017;31(6):664-675. doi:10.1037/adb0000304
8. Wilkerson RG, Kim HK, Windsor TA, Mareiniss DP. The opioid epidemic in the United States. Emerg Med Clin North Am. 2016;34(2):e1-e23. doi:10.1016/j.emc.2015.11.002
9. Xu JJ, Seamans MJ, Friedman JR. Drug overdose mortality rates by educational attainment and sex for adults aged 25-64 in the United States before and during the COVID-19 pandemic, 2015-2021. Drug Alcohol Depend. 2024;255:111014. doi:10.1016/j.drugalcdep.2023.111014
10. Bahorik AL, Satre DD, Kline-Simon AH, Weisner CM, Young-Wolff KC, Campbell CI. Alcohol, marijuana, and opioid use disorders: 5-year patterns and characteristics of emergency department encounters. Subst Abus. 2018;39(1):59-68. doi:10.1080/08897077.2017.1356789
11. Owens PL, Mutter R, Stocks C. Mental health and substance abuse-related emergency department visits among adults, 2007. In: Healthcare Cost and Utilization Project statistical brief 92. Agency for Healthcare Research and Quality; July 2010. Accessed October 10, 2023. https://pubmed.ncbi.nlm.nih.gov/21413214/
12. Kim S, Weekes J, Young MM, Adams N, Kolla NJ. Trends of repeated emergency department visits among adolescents and young adults for substance use: a repeated cross-sectional study. PLoS One. 2023;18(2):e0282056. doi:10.1371/journal.pone.0282056
13. Wettstein G. Health insurance and opioid deaths: evidence from the Affordable Care Act young adult provision. Health Econ. 2019;28(5):666-677. doi:10.1002/hec.3872
14. Lee BP, Dodge JL, Terrault NA. Medicaid expansion and variability in mortality in the USA: a national, observational cohort study. Lancet Public Health. 2022;7(1):e48-e55. doi:10.1016/s2468-2667(21)00252-8
15. Mazurenko O, Shen J, Shan G, Greenway J. Nevada’s Medicaid expansion and admissions for ambulatory care-sensitive conditions. Am J Manag Care. 2018;24(5):e157-e163.
16. Asgharian A, Neese JB, Thomas ML, Boyd AS, Huet YM. Association between the Affordable Care Act and emergency department visits for psychiatric disease. West J Emerg Med. 2023;24(3):447-453. doi:10.5811/westjem.57630
17. Saloner B, Akosa Antwi Y, Maclean JC, Cook B. Access to health insurance and utilization of substance use disorder treatment: evidence from the Affordable Care Act dependent coverage provision. Health Econ. 2018;27(1):50-75. doi:10.1002/hec.3482
18. Weinreb J, Gavrilova P, Avery J, Murphy SM, Pathak J. A nationwide analysis of US racial/ethnic disparities in emergency department patients with mental health and substance use disorders. Res Sq. Preprint posted online September 16, 2021. doi:10.21203/rs.3.rs-892560/v1
19. Kalb LG, Stapp EK, Ballard ED, Holingue C, Keefer A, Riley A. Trends in psychiatric emergency department visits among youth and young adults in the US. Pediatrics. 2019;143(4):e20182192. doi:10.1542/peds.2018-2192
20. Karaca Z, Moore BJ. Costs of emergency department visits for mental and substance use disorders in the United States, 2017. Healthcare Cost and Utilization Project statistical brief 257. Agency for Healthcare Research and Quality; May 2020. Updated October 2020. Accessed October 5, 2024. https://hcup-us.ahrq.gov/reports/statbriefs/sb257-ED-Costs-Mental-Substance-Use-Disorders-2017.jsp
21. Hawk K, D’Onofrio G. Emergency department screening and interventions for substance use disorders. Addict Sci Clin Pract. 2018;13(1):18. doi:10.1186/s13722-018-0117-1
22. Park MJ, Scott JT, Adams SH, Brindis CD, Irwin CE Jr. Adolescent and young adult health in the United States in the past decade: little improvement and young adults remain worse off than adolescents. J Adolesc Health. 2014;55(1):3-16. doi:10.1016/j.jadohealth.2014.04.003
23. Introduction to the HCUP Nationwide Emergency Department Sample (NEDS), 2020. Agency for Healthcare Research and Quality. October 2022. Updated October 6, 2022. Accessed November 19, 2023. https://hcup-us.ahrq.gov/db/nation/neds/NEDS_Introduction_2020.jsp
24. Dimick JB, Ryan AM. Methods for evaluating changes in health care policy: the difference-in-differences approach. JAMA. 2014;312(22):2401-2402. doi:10.1001/jama.2014.16153
25. Heslin KC, Elixhauser A, Steiner CA. Hospitalizations involving mental and substance use disorders among adults, 2012: Table 4 ICD-9-CM diagnosis codes defining substance use disorders. In: Healthcare Cost and Utilization Project statistical brief 191. Agency for Healthcare Research and Quality; June 2015. Accessed November 10, 2023. https://www.ncbi.nlm.nih.gov/books/NBK310986/table/sb191.t4/
26. 2025 ICD-10-CM diagnosis code F17.21: nicotine dependence, cigarettes. ICD10Data.com. Accessed November 10, 2023. https://www.icd10data.com/ICD10CM/Codes/F01-F99/F10-F19/F17-/F17.21
27. Schuur JD, Venkatesh AK. The growing role of emergency departments in hospital admissions. N Engl J Med. 2012;367(5):391-393. doi:10.1056/nejmp1204431
28. Holland KM, Jones C, Vivolo-Kantor AM, et al. Trends in US emergency department visits for mental health, overdose, and violence outcomes before and during the COVID-19 pandemic. JAMA Psychiatry. 2021;78(4):372-379. doi:10.1001/jamapsychiatry.2020.4402
29. Walley AY, Paasche-Orlow M, Lee EC, et al. Acute care hospital utilization among medical inpatients discharged with a substance use disorder diagnosis. J Addict Med. 2012;6(1):50-56. doi:10.1097/ADM.0b013e318231de51
30. Young LB, Grant KM, Tyler KA. Community-level barriers to recovery for substance-dependent rural residents. J Soc Work Pract Addict. 2015;15(3):307-326. doi:10.1080/1533256x.2015.1056058
31. Oser CB, Leukefeld CG, Tindall MS, et al. Rural drug users: factors associated with substance abuse treatment utilization. Int J Offender Ther Comp Criminol. 2011;55(4):567-586. doi:10.1177/0306624X10366012
32. Suen LW, Makam AN, Snyder HR, et al. National prevalence of alcohol and other substance use disorders among emergency department visits and hospitalizations: NHAMCS 2014-2018. J Gen Intern Med. 2022;37(10):2420-2428. doi:10.1007/s11606-021-07069-w
33. McCoy SJ, McDonough I, Roychowdhury P. The impact of terrorism on social capital: evidence from the 2015 Charlie Hebdo Paris shooting. Oxf Bull Econ Stat. 2020;82(3):526-548. doi:10.1111/obes.12343
34. Rosenbaum S. The Patient Protection and Affordable Care Act: implications for public health policy and practice. Public Health Rep. 2011;126(1):130-135. doi:10.1177/003335491112600118
35. Sommers BD, Gunja MZ, Finegold K, Musco T. Changes in self-reported insurance coverage, access to care, and health under the Affordable Care Act. JAMA. 2015;314(4):366-374. doi:10.1001/jama.2015.8421
36. Saloner B, Bandara SN, McGinty EE, Barry CL. Justice-involved adults with substance use disorders: coverage increased but rates of treatment did not in 2014. Health Aff (Millwood). 2016;35(6):1058-66. doi:10.1377/hlthaff.2016.0005
37. Drug overdose deaths in the U.S. top 100,000 annually. News release. CDC. November 17, 2021. Accessed October 19, 2023. https://www.cdc.gov/nchs/pressroom/nchs_press_releases/2021/20211117.htm
38. Rudd RA, Aleshire N, Zibbell JE, Gladden RM. Increases in drug and opioid overdose deaths — United States, 2000-2014. MMWR Morb Mortal Wkly Rep. 2016;64(50-51):1378-1382. doi:10.15585/mmwr.mm6450a3
39. Ali MM, Teich JL, Mutter R. Reasons for not seeking substance use disorder treatment: variations by health insurance coverage. J Behav Health Serv Res. 2017;44(1):63-74. doi:10.1007/s11414-016-9538-3
40. Mojtabai R. National trends in long-term use of prescription opioids. Pharmacoepidemiol Drug Saf. 2018;27(5):526-534. doi:10.1002/pds.4278
41. Kravitz-Wirtz N, Davis CS, Ponicki WR, et al. Association of Medicaid expansion with opioid overdose mortality in the United States. JAMA Netw Open. 2020;3(1):e1919066. doi:10.1001/jamanetworkopen.2019.19066
42. Wen H, Hockenberry J, Cummings JR. The effect of substance use disorder treatment use on crime: evidence from public insurance expansions and health insurance parity mandates. National Bureau of Economic Research working paper 20537. October 2014. Accessed August 1, 2025. https://www.nber.org/papers/w20537
43. Maclean JC, Saloner B. The effect of public insurance expansions on substance use disorder treatment: evidence from the Affordable Care Act. J Policy Anal Manage. 2019;38(2):366-393.
44. Garthwaite C, Gross T, Notowidigdo M, Graves JA. Insurance expansion and hospital emergency department access: evidence from the Affordable Care Act. Ann Intern Med. 2017;166(3):172-179. doi:10.7326/M16-0086
45. Koh HK, Sebelius KG. Promoting prevention through the Affordable Care Act. N Engl J Med. 2010;363(14):1296-1299. doi:10.1056/NEJMp1008560
46. Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain—United States, 2016. JAMA. 2016;315(15):1624-1645. doi:10.1001/jama.2016.1464
47. Patrick SW, Fry CE, Jones TF, Buntin MB. Implementation of prescription drug monitoring programs associated with reductions in opioid-related death rates. Health Aff (Millwood). 2016;35(7):1324-1332. doi:10.1377/hlthaff.2015.1496
48. Tedesco D, Asch SM, Curtin C, et al. Opioid abuse and poisoning: trends in inpatient and emergency department discharges. Health Aff (Millwood). 2017;36(10):1748-1753. doi:10.1377/hlthaff.2017.0260
49. Garfield R, Orgera K, Damico A. The uninsured and the ACA: a primer - key facts about health insurance and the uninsured amidst changes to the Affordable Care Act. KFF. January 25, 2019. Accessed September 11, 2024. https://www.kff.org/uninsured/report/the-uninsured-and-the-aca-a-primer-key-facts-about-health-insurance-and-the-uninsured-amidst-changes-to-the-affordable-care-act/
50. Karaca-Mandic P, Norton EC, Dowd B. Interaction terms in nonlinear models. Health Serv Res. 2012;47(1, pt 1):255-274. doi:10.1111/j.1475-6773.2011.01314.x
Stay ahead of policy, cost, and value—subscribe to AJMC for expert insights at the intersection of clinical care and health economics.