Bradley Monk, MD, FACOG, FACS, clinician at Arizona Oncology, professor at the University of Arizona and Creighton University in Phoenix, discusses the reimbursement of PARP inhibitors in ovarian cancer.
Bradley Monk, MD, FACOG, FACS, clinician at Arizona Oncology, professor at the University of Arizona and Creighton University in Phoenix, head of the US Oncology Gynecologic Research Committee, and current co-director for the Gynecologic Oncology Group Research Consortium, discusses the reimbursement landscape of PARP inhibitors in ovarian cancer.
Transcript
How has the reimbursement landscape for PARP inhibitors evolved since the first one was approved? Do patients have any access issues that are driven by reimbursement decisions?
Reimbursement for PARP inhibition has been universal in the United States and even in Europe. These new frontline PARP inhibitor indications of PRIMA [trial] and the PAOLA-1 [trial]—PRIMA niraparib alone, PAOLA-1 bevacizumab and olaparib—have now been approved in Europe. Europe is trafficking through reimbursement, but in the United States are universally paid for. The only caveat is that in the bevacizumab-olaparib combination there is a companion diagnostic, so generally reimbursement is only for those patients that have the molecular HRD [homologous recombination deficiency] signature.
Even though PARP inhibitors have been paid for through insurances, which is universally true, there are still copays, and copays are the real financial burden. The companies try to support through copay assistance programs, they have foundations, but there still is a substantial financial burden to these expensive oral medications. Someday there'll be generic, and we already have multiple biosimilars for bevacizumab, and we're seeing the prices come down.
So in the end, it's all about value. And the value of PARP inhibitors, obviously, is the most in BRCA-mutated patients—either germline or somatic, it's about the same—but also a lot of value in the HRD, BRCA-like gene subset. The value in the patients that are what we call homologous recombination proficient is not as much, but they're still approved, and certainly there is a value issue with bevacizumab. And when you add bevacizumab and olaparib together, then obviously 2 medications are more expensive than 1.
Overcoming Employment Barriers for Lasting Social Impact: Freedom House 2.0 and Pathways to Work
April 16th 2024To help celebrate and recognize National Minority Health Month, we are bringing you a special month-long podcast series with our Strategic Alliance Partner, UPMC Health Plan. Welcome to our second episode, in which we learn all about Freedom House 2.0 and the Pathways to Work program.
Listen
An Overview of Health Care and Pharmaceutical Trends, 2023-2024
April 19th 2024Douglas M. Long, BA, MBA, was featured as the keynote speaker on the closing day of The Academy of Managed Care Pharmacy 2024 annual meeting, with a session dedicated to surveying the health care and pharmaceutical trends of the last year.
Read More
Making Giant Strides in Maternity Health Through Baby Steps
April 9th 2024To help celebrate and recognize National Minority Health Month, we are kicking off a special month-long podcast series with our strategic alliance partner, UPMC Health Plan. Welcome to our first episode, which is all about the Baby Steps Maternity Program and its mission to support women throughout every step of their pregnancy journey.
Listen
Prices for care at hospital trauma centers vary across hospitals; drug shortages reached a record high during the first quarter of 2024; although 3 of the biggest makers of asthma inhalers pledged to cap out-of-pocket costs for some US patients at $35, these do not apply to daily inhalers used by the youngest kids with asthma.
Read More