Video

Dr David Snyder on When to Add Ruxolitinib to Treat GVHD

Ruxolitinib should be added to treatment of patients with graft-versus-host disease (GVHD) are not improving on steroids or whose symptoms return after tapering, said David Snyder, MD, associate chair of the Department of Hematology & Hematopoietic Cell Transplantation at City of Hope.

Ruxolitinib should be added to treatment of patients with graft-versus-host disease (GVHD) are not improving on steroids or whose symptoms return after tapering, said David Snyder, MD, associate chair of the Department of Hematology & Hematopoietic Cell Transplantation at City of Hope.

Transcript

When should treatment for graft-versus-host disease be switched from steroids to ruxolitinib?

Well, the studies that were done using ruxolitinib as salvage therapy defined steroid refractoriness by a few parameters. One is that a patient has been on corticosteroids at a certain dose for these 5 days with no significant response or 7 days in some studies. Or that the patient has been on steroids for that length of time and then you’re unable to taper off the steroids without seeing the GVHD flare. Those are the situations where you would consider adding ruxolitinib.

Related Videos
Dr Emma Achola-Kothani
Marla Black Morgan, MD, Phoebe Neurology Associates
Christine Funke, MD
5 experts are featured in this series
5 experts are featured in this series
Toby Maher, MD, PhD, professor of clinical medicine, Keck School of Medicine at USC
Nini Wu, MD, Navista
Fred Locke, MD, Moffitt Cancer Center and Research Institute
Dr Emma Achola-Kothari
Matthew Viggiano, MD, internal medicine resident, Temple University Hospital
Related Content
AJMC Managed Markets Network Logo
CH LogoCenter for Biosimilars Logo