Dr Mark Wildgust: Daratumumab Critical to Improving Patient Response

January 25, 2021

Daratumumab represents an important addition to the armamentarium of care for improving patient outcomes, said Mark Wildgust, PhD, vice president of Global Medical Affairs/Oncology at Janssen.

Daratumumab, alone and in combination with a proteasome inhibitor and immunomodulation, represents an important addition to the armamentarium of care for improving patient outcomes, especially response rate and progression-free survival, noted Mark Wildgust, PhD, vice president of Global Medical Affairs/Oncology at Janssen.

Transcript

Why have immunomodulatory drugs been so successful in relapsed/refractory multiple myeloma?

I think we've learned that immunomodulatory agents like lenalidomide [Revlimid] and pomalidomide have been quite effective. I think if you go back a couple of steps in terms of how we've got to where we are today, we saw thalidomide become a really important component of care. We're kind of moving then from that older chemotherapy-based regimen approach. You saw agents like thalidomide coming forward—brand new mechanism of action, modulating the microenvironment and seeing improvements. We then saw proteasome inhibitors [PIs] come forward, like Velcade. And then we saw them being used by themselves, then we saw them being used with IMiDs [immunomodulatory drugs].

And I think today what we see is that IMiDs are an important component of care. But going back to daratumumab for a second, I think that if you look at the magnitude of benefit that we're adding when we're adding daratumumab to these regimens, it's really clear today that daratumumab is in itself a critical, essential agent in terms of improving outcomes for patients.

And so I think we're at a point now where we can build regimens, like daratumumab plus a PI plus an IMiD, and we can get these very, very high response rates, depth of response, and improvement in PFS [progression-free survival]. And I think building those regimens today is really important. But I think daratumumab is a key part of that, and an IMiD is a piece of that, whether it be thalidomide, Revlimid, or pomalidomide.