Patricia Deverka, MD, MS, senior researcher, deputy director at the Center for Translational and Policy Research and Precision Medicine, University of California San Francisco, explains what multicancer early detection tests currently exist and the research needed to understand their clinical utility.
Patricia Deverka, MD, MS, senior researcher, deputy director at the Center for Translational and Policy Research and Precision Medicine, University of California San Francisco, explains what multicancer early detection tests (MCEDs) currently exist and the research needed to understand their clinical utility.
Transcript
What access to multicancer early detection tests do patients currently have? How do they typically pay for them right now?
Currently, the only multicancer early detection test that's on the market is called Galleri, and the company website for Galleri indicates that providers and health systems and employers are their intended target audience. They have information about that. But it is currently not covered by insurance. The price listed on the website is $949 and it appears that self-pay is the only option. At this point, even though employers may be some of their target audience, it's unclear whether they could use their HSA [health savings account] or FSA [flexible spending account] accounts to pay for the test.
What additional testing and research is needed to understand the clinical utility and cost-effectiveness of liquid biopsy screening?
In terms of what additional testing and research is needed to understand the clinical utility of MCED testing, I think, first, there really needs to be a shared understanding of how we're going to even assess the clinical utility of these tests. Is it that each cancer will be looked at individually, so the clinical utility of screening for that type of cancer, or for the test as a whole?
If we all agree that clinical utility means studies that demonstrate that the test results affect clinical decisions and improve health outcomes, then can this be done across tumor types, some of which have current standard of care screening options, and others which do not? I think that's a whole very complex area where we just have to agree by what do we mean by clinical utility.
I really do think there need to be large, pragmatic clinical trials, such as those that are occurring now, like for the National Health Service in England with the Galleri tests that I mentioned earlier, as well as other real-world evidence studies that look at longitudinal outcomes across patient subgroups and health care delivery settings. Because, as I already mentioned, there is at least 1 test already on the market in the US and these studies are either in the planning stages or some of them are ongoing, I think that there need to be models that estimate the survival benefits of downstaging cancer detection across multiple cancer types. I think that will help to estimate the ability to detect multiple cancers simultaneously.
CMS' 340B Repayment Proposal May Harm Vulnerable Hospitals, Reward Those With Higher Revenues
April 26th 2024The 340B hospitals not receiving an offsetting lump-sum payment from CMS following 2018-2022 cuts later ruled unlawful are disproportionately rural, publicly owned, and nonacademic, according to a new study.
Read More
Examining Low-Value Cancer Care Trends Amidst the COVID-19 Pandemic
April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
Listen
Empowering Community Health Through Wellness and Faith
April 23rd 2024To help celebrate and recognize National Minority Health Month, we are bringing you a special month-long podcast series with our Strategic Alliance Partner, UPMC Health Plan. In the third episode, Camille Clarke-Smith, EdD, MS, CHES, CPT, discusses approaching community health holistically through spiritual and community engagement.
Listen
Mental Health Diagnoses, Care Challenges Rise Among US Youth, Report Finds
April 26th 2024While behavioral health care utilization has been rising, the treatment landscape has been worsening. New findings show that 20% of youths did not receive any form of treatment within 3 months of their initial behavioral health diagnosis.
Read More