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Genetic Testing Shines Light on Diabetes-Related Complications
As a new era of personalized medicine continues to provide clues between genetic makeups and predispositions to certain disease states, researchers and providers are able to come up with more targeted therapies for patient populations.
As a new era of personalized medicine continues to provide clues between genetic makeups and predispositions to certain disease states, researchers and providers are able to come up with more targeted therapies for patient populations. Here are some recent studies that have been released at the ADA 72nd Scientific Sessions that are helping to provide insights into the correlation between diabetes and other disease states.
A Genome-Wide Association Analysis of Coronary Calcification in the Diabetes Heart Study - Cox et al.
Genetic risk factors for cardiovascular disease in patients with type 2 diabetes may reveal biological pathways that can help explain the increased risk of macrovascular complications in type 2 diabetes. Cox et al examined the association signals for sub-clinical cardiovascular disease in analyses restricted to patients with type 2 diabetes by performing a genome-wide association study (GWAS) for coronary artery calcified plaque in the family-based Diabetes Heart Study. The findings of this analysis suggest there is potential for novel GWAS signals for coronary calcification in type 2 diabetes. The research team concluded that a meta-analysis of vascular calcification signals in type 2 diabetes cohorts “should further elucidate these relationships and identify variants contributing to risk for vascular calcification” in type 2 diabetes patients.
Development of Risk Prediction Models for Chronic Kidney Disease in Type 2 Diabetes Using Genetic and Clinical Variables - Jiang et al.
As Vupputuri et al documented in their “Chronic-Kidney Disease Progression and Associated Medical Costs in Type 2 Diabetes” study, chronic kidney disease (CKD) is not only a common complication associated with type 2 diabetes, but it is also a costly one. In this study, Jiang et al aimed to examine the prevalence of stage 5 CKD and use of renal replacement therapy (RRT) in the Scottish population with diabetes to determine “the primary renal diagnosis (PRD) among those on RRT and to test whether survival following RRT varies by PRD." The research team performed this analysis by linking records from the national database of all those registered with diabetes in 2006-2008 to the Scottish Renal Registry, which captures all RRT recipients in Scotland. Jiang et al concluded that “mortality rates after starting RRT were not significantly different in diabetic versus non-diabetic kidney disease among those with type 2 diabetes in this study.”
To read more about this study, please visit the American Diabetes Association’s website.
POSITIVE Trial Update on Patients With Breast Cancer Attempting Pregnancy
December 8th 2023At last year’s San Antonio Breast Cancer Symposium, POSITIVE trial primary outcome data were presented on breast cancer–free interval, with women who paused endocrine therapy to attempt pregnancy having a similarly small rate of recurrence vs external controls from the SOFT and TEXT trials: 8.9% vs 9.2%.
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The Importance of Examining and Preventing Atrial Fibrillation
August 29th 2023At this year’s American Society for Preventive Cardiology Congress on CVD Prevention, Emelia J. Benjamin, MD, ScM, delivered the Honorary Fellow Award Lecture, “The Imperative to Focus on the Prevention of Atrial Fibrillation,” as the recipient of this year’s Honorary Fellow of the American Society for Preventive Cardiology award.
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Refining Precision Prevention for Benign Breast Disease
December 7th 2023Many questions remain surrounding accurately classifying the risk of developing invasive breast cancer associated with the benign breast disease diagnoses of nonproliferative lesions and proliferative changes without atypia.
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Promoting Equity in Public Health: Policy, Investment, and Community Engagement Solutions
June 28th 2022On this episode of Managed Care Cast, we speak with Georges C. Benjamin, MD, executive director of the American Public Health Association, on the core takeaways of his keynote session at AHIP 2022 on public health policy and other solutions to promote equitable health and well-being.
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ASH 2023 to Highlight Options in Care for Blood Diseases—for Those Who Have Access
December 7th 2023The 65th American Society of Hematology (ASH) Annual Meeting & Exposition, which runs Friday through Tuesday in the San Diego Convention Center, will showcase the growing number of treatment choices in blood cancers and disorders.
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Race/Ethnicity May Influence Local Recurrence in DCIS, Adjuvant Treatment
December 6th 2023Disparities in 10-year local recurrence following breast-conserving surgery were seen among women with ductal carcinoma in situ (DCIS) treated over a nearly 4-decade span at Memorial Sloan Kettering Cancer Center, with Black women having the highest rate.
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