- Center on Health Equity and Access
- Clinical
- Health Care Cost
- Health Care Delivery
- Insurance
- Policy
- Technology
- Value-Based Care
Imaging CAR T Cells Will Assist Doctors' Treatment Strategies, Says Dr Reona Sakemura
Predicting T-cell toxicity is a key factor when it comes to successfully using CAR T-cell therapy, said Reona Sakemura, MD, PhD, postdoctoral researcher at the Mayo Clinic.
Imaging CAR T-cells Will Assist Doctors' Treatment Strategies, Says Dr Reona Sakemura
Transcript:
How will being able to assess CAR T-cell expansion, trafficking, and toxicity, help improve successful use of these therapies?
Imaging CAR T-cells in vivo will potentially allow us to assist scar tissue expansion traffic into tumor sites. In order to do so, we incorporate NIS, which is sodium iodide symporter, into CAR T-cells to visualize CAR T-cells in vivo. By using this technology we may be able to change the treatment strategy when the CAR T-cells are not expanding properly or there’s not traffic into tumor sites. If we are able to predict the CAR T-cell toxicity, prompt intervention may be initiated.
Do we know how often CAR T-cells are not trafficking to the right area duing treatment?
So we don't really know that yet. This is kind of like a hypothesis, that why CAR T-cells are not working in solid tumors. We think that the trafficking is a problem. So if you can assist that by imaging, that will help us a lot to figure out what's going on, or maybe you can use the other antigen to direct CAR T-cells.
Dr Dalia Rotstein: Physicians Must Be Aware MS Affects People of All Backgrounds
April 24th 2024Dalia Rotstein, MD, MPH, emphazises the importance of awareness that multiple sclerosis (MS) impacts patients from various backgrounds as clinicians think through ways to improve access to care and research efforts in MS.
Read More
Empowering Community Health Through Wellness and Faith
April 23rd 2024To help celebrate and recognize National Minority Health Month, we are bringing you a special month-long podcast series with our Strategic Alliance Partner, UPMC Health Plan. In the third episode, Camille Clarke-Smith, EdD, MS, CHES, CPT, discusses approaching community health holistically through spiritual and community engagement.
Listen
Beyond Insulin: The Impact of Next-Generation Diabetes Technology
April 17th 2024Experts explain how new diabetes technologies like continuous glucose monitors are transforming care beyond intensive insulin therapy, offering personalized insights and improving outcomes for patients of all treatment levels.
Read More
Overcoming Employment Barriers for Lasting Social Impact: Freedom House 2.0 and Pathways to Work
April 16th 2024To help celebrate and recognize National Minority Health Month, we are bringing you a special month-long podcast series with our Strategic Alliance Partner, UPMC Health Plan. Welcome to our second episode, in which we learn all about Freedom House 2.0 and the Pathways to Work program.
Listen
Increasing Lp(a) Awareness for Better Cardiovascular Health: Dr Mary McGowan
March 24th 2024For Lp(a) Awareness Day, Mary McGowan, MD, FNLA, chief medical officer of the Family Heart Foundation, highlights how most people with elevated Lp(a) are completely unaware that they have this increased risk and calls for increased testing.
Read More
