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Overcoming High Costs to Provide Affordable Access to Cancer Care

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As what happens many times when cancer drugs gain FDA approval, the statistically significant improvements in regards to prolonging patients' lives is often offset by high drug costs, which makes it difficult for drug companies and payers to provide patients access to lifesaving treatments. But what can be done to improve access to affordable care?

On June 8, the FDA approved the injection pertuzumab for “use in combination with trastuzumab and docetaxel for the treatment of patients with HER2-postive metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease.” As what happens many times when cancer drugs gain FDA approval, the statistically significant improvements in regards to prolonging patients’ lives is often offset by high drug costs, which makes it difficult for drug companies and payers to provide patients access to lifesaving treatments.

The cost of developing cancer drugs can be exorbitant, sometimes in the billions of dollars. In addition, many cancer drugs never even make it to market, meaning that the company is unable to recoup the costs. So, in situations where drugs such as pertuzumab garner approval, the pricing for treatment is often high. According to Breast Cancer Action, “initial information regarding cost has indicated that a course of treatment with pertuzumab and trastuzumab could cost approximately $200,000,” resulting in a price tag that “inevitably limits availability, especially to already underserved communities.”

So, what is the solution? That’s the billion dollar question; unfortunately, there is no silver bullet answer. However, one thing is for certain—payment models need to change. Accountable Care Organizations and bundled payments are two models that have the potential to overhaul the system, but there are still many obstacles. Lee Newcomer, MD, MHA, recently spoke about this topic in AJMC’s most recent roundtable on the treatment and cost implications of pertuzumab, saying that payment models need to be adjusted so that financing approaches work off of budgets.

“A budget would require physicians to separate out those things that are really important from those that either don’t have an effect or don’t have enough of an effect to be important. I really believe those decisions are best made at the professional level, so I am hoping that as we evolve into new financing systems that it will be doctors involved in making the decision. But…that is going to be hard. Looking at a patient and saying we aren’t going to do some of these things because they just don’t have value, even if a patient may want them, is going to be very difficult to do.”

Sandra M. Swain, MD, President of the American Society of Clinical Oncology (ASCO) also spoke about some of the programs that have been launched to assist in lowering healthcare costs and implementing payment reform models. Dr Swain talked about ASCO’s Quality Oncology Practice Initiative (QOPI), which has helped provide over 700 practices with quality measurement and improvement tools, as well as their Choosing Wisely campaign, which asked oncologists to provide their “top 5 list of tests and treatments that are commonly performed in their respective fields despite a lack of evidence that they provide meaningful benefit to major categories of patients.” The list, which can be viewed on ASCO’s website, represent the most significant opportunities to improve quality and care in cancer care today. “We need to link that now to outcomes and I think that’s really one of the basic areas of research that’s being done — if you make these changes will the outcomes actually be better,” Dr Swain said.

Drs Newcomer and Swain also spoke about other strategies on the horizon that have the potential to decrease healthcare costs but that have not yet evolved to the point of making an impact, such as value-based coinsurance and copays. Although value-based models have not yet been simplified to the point of feasibility, Dr Swain mentioned that companion diagnostics represent an important opportunity to cut costs. “Companion diagnostics are really very important to be approved with the newer drugs...so that also sets a higher bar for the new drugs that are coming out. Plus, it decreases the population of patients in which the drug is being tested, so the clinical trials in the future should cost less, and then, hopefully in the future the drugs will also cost less. So, that’s something where research is really important to decrease some of these costs.”

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