Prior Authorization and Access to Targeted Treatment for Ph+ ALL Patients

Jonathan Abbas, MD, compares the safety and effectiveness of different targeted agents and considerations when selecting a frontline regimen for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

This is a video synopsis/summary of a Peer Exchange involving: Ryan Haumschild, PharmD, MS, MBA; Jonathan Abbas, MD; Elias Jabbour, MD; James K. McCloskey, MD; Vivian Tambe Ebot-Tar, PharmD, MBA.

The discussants focused on decision-making for selecting optimal frontline Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) treatment, balancing efficacy and safety. Dr Abbas emphasized assessing ponatinib candidacy early on, given its higher potency and unique adverse effect profile requiring extensive cardiac screening. He noted that if patients cannot receive ponatinib, the approach may shift toward allogeneic stem cell transplant. Dr Ebot-Tar discussed payer strategies to facilitate timely access without administrative barriers. She highlighted the value of provider input on pharmacy and therapeutics committees when making coverage determinations for specialized disease states like Ph+ ALL.

Video synopsis is AI-generated and reviewed by AJMC® editorial staff.

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