Prior Authorization and Access to Targeted Treatment for Ph+ ALL Patients

EP: 1.Overview of Characteristics Unique to Ph+ ALL

EP: 2.Timely Detection: Incidence and Prevalence of Ph+ ALL

EP: 3.Supporting Ph+ ALL Patient: Emotional Challenges and Quality of Life

EP: 4.Screening and Diagnosing of Ph+ ALL in Adults

EP: 5.Diagnosis and Treatment Timeline: Different Phases of Ph+ ALL Management

EP: 6.Current Front-Line Targeted Treatments in Ph+ ALL

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EP: 7.Prior Authorization and Access to Targeted Treatment for Ph+ ALL Patients

EP: 8.PhALLCON Trial: Efficacy and Safety of Ponatinib in Ph+ ALL Patients

EP: 9.Value-Based Care Models Optimizing Ph+ ALL Patient Care

EP: 10.Unmet Needs in Screening, Diagnosis, and Management of Ph+ ALL

EP: 11.Disparities in Access to Care for Ph+ ALL patients

EP: 12.The Future of Ph+ ALL Treatments

EP: 13.Concluding Thoughts on Ph+ ALL Treatment

This is a video synopsis/summary of a Peer Exchange involving: Ryan Haumschild, PharmD, MS, MBA; Jonathan Abbas, MD; Elias Jabbour, MD; James K. McCloskey, MD; Vivian Tambe Ebot-Tar, PharmD, MBA.

The discussants focused on decision-making for selecting optimal frontline Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) treatment, balancing efficacy and safety. Dr Abbas emphasized assessing ponatinib candidacy early on, given its higher potency and unique adverse effect profile requiring extensive cardiac screening. He noted that if patients cannot receive ponatinib, the approach may shift toward allogeneic stem cell transplant. Dr Ebot-Tar discussed payer strategies to facilitate timely access without administrative barriers. She highlighted the value of provider input on pharmacy and therapeutics committees when making coverage determinations for specialized disease states like Ph+ ALL.

Video synopsis is AI-generated and reviewed by AJMC® editorial staff.