The aDCSI without the inclusion of laboratory data performs similarly to the DCSI with laboratory results, and is a good measure of diabetes severity.
To test the validity of the adapted Diabetes Complications Severity Index (aDCSI), which does not include laboratory test results, as an indicator of diabetes severity.
Retrospective cohort study using 4 years of claims data from 7 health insurance plans.
Individuals with diabetes mellitus and continuous enrollment were study subjects (N = 138,615). The 2 independent variables—the aDCSI score (sum of 7 diabetes complications graded by severity as 0, 1, or 2; range 0-13) and the aDCSI diabetes complication count (sum of 7 diabetes complications without severity grading; range 0-7)—were generated using only claims data. We evaluated the numbers of hospitalizations attributable to the aDCSI with Poisson regression models, both categorically and linearly.
The aDCSI score (risk ratio 1.39 to 6.10 categorically and 1.41 linearly) and diabetes complication count (risk ratio 1.67 to 9.11 categorically and 1.65 linearly) were both significantly positively associated with the number of hospitalizations over a 4-year period. Risk ratios from the aDCSI score were very similar to the risk ratios previously reported for the Diabetes Complications Severity Index (DCSI); the absolute difference between risk ratios ranged from 0.01 to 1.6 categorically and was 0.05 linearly.
The aDCSI is a good measure of diabetes severity, given its ability to explain hospitalizations and its similar performance to the DCSI.
(Am J Manag Care. 2012;18(11):721-726)The adapted Diabetes Complications Severity Index (aDCSI), which does not include laboratory test results, is a good measure of diabetes severity.
Diabetes mellitus is one of the major healthcare issues in the United States because of its high prevalence and the growing costs of caring for affected patients.1-3 Complications associated with diabetes drive the escalating costs of diabetes management. Although several risk measures were developed to quantify the severity of diabetes complications, they mostly targeted a specific condition instead of the broad array of diabetes complications.4-6 The Diabetes Complications Severity Index (DCSI), developed by Young and colleagues, uniquely incorporates a wide range of diabetes complications.7 The DCSI incorporates diagnosed complications along with select laboratory results to assess patients’ risks of adverse outcomes, including hospitalizations and death. It uses information from 7 diabetes complication categories.7 Even though the DCSI is a relatively new measure, it has been quickly adopted by researchers.8-12 However, DCSI’s utility as a risk measure to characterize a diabetic population may be limited because laboratory test results are not readily available to researchers, particularly those who rely on administrative claims.
Risk measures have increasingly relied on claims data because they are inexpensively available for a great number of individuals; these data include claims for diagnoses and procedures and often information on dispensed medications.13,14 One widely used risk adjustment measure, the Adjusted Clinical Group system, uses an individual’s diagnoses and pharmacy data from 1 year to assign a morbidity level.15 This approach has been validated both domestically16 and internationally.17,18 However, claims data usually do not include laboratory information, which makes it difficult for risk measures that require laboratory results to be applied on a large scale.
Therefore, our purpose was to test the validity of the adapted Diabetes Complications Severity Index (aDCSI), which excludes laboratory test results, as an indicator of diabetes severity. We hypothesized that the aDCSI would be comparable to the DCSI (which includes laboratory data) and be a good measure of diabetes severity.
RESEARCH DESIGN AND METHODSDesign
This was a retrospective cohort study using 4 years of claims data in which we tested the value of the aDCSI for explaining the number of hospitalizations.
We accessed claims data from 7 Blue Cross Blue Shield plans; the detailed information was described in a published paper.19 The original data were collected from 2002 to 2005; the data were subsequently updated with additional data on the original individuals through 2006. The following data were acquired: (1) enrollment files for administrative data; (2) benefits information to determine medical and pharmacy coverage; and (3) inpatient, outpatient, and pharmacy claims records containing the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis, Current Procedural Terminology codes, and National Drug Code prescription information.
Defining the Analytic Cohort
We required that the enrollees have type 2 diabetes, and full medical and pharmacy coverage in the 4-year period.
We defined individuals as having type 2 diabetes if they had 1 relevant inpatient code or 2 outpatient ICD-9-CM codes separated by at least 30 days. The relevant codes were 250.xx, 648.0 (diabetes mellitus with pregnancy), and 362.0 (diabetic retinopathy) or 266.41 (diabetic cataract). Individuals only with 250.x3 (type 1 diabetes) were not included. Additionally, any individual filling a prescription for a medication for treatment of hyperglycemia was included (, available at www.ajmc.com). Combination medications were also identified. If the prescription was for metformin alone, the individual was also required to have an ICD-9-CM code for diabetes for inclusion in this group. The calendar year of the earliest diagnosis of diabetes was used as the starting point of the observation period.
Number of Hospitalizations and Costs
The number of hospitalizations was obtained from the inpatient claims over a 4-year period. Costs were obtained from the claims over a 4-year period; per person per year total costs and pharmacy costs were presented. Total costs were examined as well as pharmacy costs.20
DCSI Scores and DCSI Complication Counts
To replicate the DCSI scores and DCSI complication counts, we identified the claims coded with the ICD-9-CM system for individuals during the 4-year study period and applied the classification method developed by Young and colleagues ().7 The DCSI score consists of scores (0, 1, or 2) from 7 complication categories: retinopathy, nephropathy, neuropathy, cerebrovascular, cardiovascular, peripheral vascular disease, and metabolic; it ranges from 0 to 13. The DCSI complication count is a count of any complication in the 7 categories and ranges from 0 to 7. We did not include laboratory results in constructing these aDCSI scores and aDCSI complication counts.
For number of hospitalizations, we adopted a Poisson model with adjustment for overdispersion, to parallel what Young and colleagues did. Given that there were many people without any hospitalizations, a zero-inflated negative binomial model was also used for a sensitivity analysis. The patterns of results from both models were similar, so we just report the results from the Poisson model.
We calculated risk ratios for hospitalization. We tested inclusion of the main independent variables, aDCSI score and aDCSI complication count, categorically (0, 1, 2, 3, 4, 5+) and linearly. In categorical analysis, the risk ratio of hospitalizations was derived by comparing samples in a given category with those in category 0; in linear analysis, it was the risk ratio of hospitalizations associated with a 1-unit increase in aDCSI score.
Comparison of DCSI With and Without Laboratory Test Results
We compared the risk ratios of hospitalizations obtained in this study with those in the study by Young et al to determine whether the aDCSI (without laboratory information) and the DCSI (with laboratory information) perform similarly. Given the differences in study population and sample size, we decided that if the risk ratios from both sources were similar and showed similar patterns across risk groups, we would conclude that the aDCSI and DCSI performed similarly.
The data were deidentified in accordance with the Health Insurance Portability and Accountability Act’s definition of a limited data set. The Johns Hopkins University Office of Research Subjects deemed the study to be exempt from federal regulations because the research activities were considered to be of minimal risk to subjects, as they were not identifiable.
RESULTSCharacteristics of the Study Samples
There were 138,615 study subjects (). The mean age was about 59 years and roughly 51% were male. About 70% of the study subjects had a score of 0 for DCSI score/complication count, and close to 60% had no hospitalization. The mean aDCSI score, aDCSI complication count, and number of hospitalizations were 0.50, 0.37, and 0.94, respectively. The average annual total cost was $11,500 over a 4-year period, of which $3000 (26%) was pharmacy cost.
With Laboratory Versus Without Laboratory
Without laboratory data, aDCSI score and aDCSI complication count were significantly positively associated with the number of hospitalizations over a 4-year period. Categorically, risk ratios ranged from 1.39 to 6.10 for aDCSI score and from 1.67 to 9.11 for aDCSI complication count, when comparing the non-zero categories (from 1 to 5+) with the category 0. Linearly, the risk ratio was 1.41 for each 1-unit increase in aDCSI score and 1.65 for each additional aDCSI complication count ().
Compared with the DCSI with laboratory data used by Young et al,7 risk ratios for hospitalization as determined by aDCSI score were very similar when the score was less than or equal to 3, and a little lower when the score was above 3 (). The absolute difference in risk ratios between our results and those of Young et al increased as the score category increased, ranging from 0.01 to 1.6. Linearly, the risk ratio for aDCSI score was a little higher than that for DCSI score (1.41 vs 1.36). Similar patterns were observed using the DCSI complication count (Table 2).
We found that even without inclusion of laboratory test results, the aDCSI can be used to explain hospitalization. The similarities of the risk ratios determined by the DCSI with and without laboratory results suggest that the DCSI might be applied when laboratory data are not available.
Removing the requirement of including laboratory results will expand the usefulness of the DCSI. Claims data are routinely collected by health insurers for the purpose of reimbursement. Many health-related measures have been constructed using only the information in claims so that these measures can be applied widely.
In this study we compared risk ratios derived from 2 different data sets. Differences existed between these 2 samples; compared with our sample, the sample used by Young and colleagues7 was much smaller (4229 vs 138,615), was older (63 vs 59 years), and had slightly more men (51.8% vs 50.7%). Additionally, their population had more diabetes complications (32%, 32%, and 36% had 0, 1, and 2+ complications vs 72%, 22%, and 6% in our study) and had a higher mean DCSI score (1.74 vs 0.50). These differences may be partially explained by exclusion of individuals with type 1 diabetes from our sample. Despite these differences, the risk ratios of hospitalization from both samples were comparable.
The important difference in sample size resulted in the much smaller 95% confidence intervals for both DCSI score and complication count across all levels (Table 2). In addition, the large disparity in comorbidity between the 2 samples might have contributed to the larger difference in risk ratios for the 5+ category that we observed between 2 studies. Young and colleagues’ study population included more patients with 2 or more complications (36.4%) than our study population did (6.8%). We suspect that the patients in the Young et al study who had 5 or more complications were sicker than ours (eg, had 8 or 9 complications) within that category. Combined with the observation that the magnitude of risk ratio increased as the DCSI score and complication count increased, their risk ratio was higher than ours.
Our study had several potential limitations. First, this data set did not contain the laboratory data. Ideally, the comparison of the performance between the DCSI and aDCSI would have been made using information from the same study subjects. However, given the lack of laboratory data, this could not be done. Second, the mortality information was not available in our data. In the study by Young et al, the relationship between mortality and the DCSI was also examined. If this relationship could also be explored, that would further strengthen the conclusion that the aDCSI performs as well as the DCSI with laboratory data. Furthermore, the DCSI might be further refined using the pharmacy information included in claims data. Inclusion of this information might enable the DCSI to even better predict an individual’s risk of hospitalization or death, and provide an estimate of the severity of his/her diabetes.
The aDCSI, which does not include laboratory data, is a good measure of diabetic severity, given its ability to explain hospitalizations and its similar performance to the DCSI, which does include laboratory results.Acknowledgments
The data set used in this current study was originally created for a different research project on patterns of obesity care within selected Blue Cross/Blue Shield (BCBS) plans. The previous research project (but not the current study) was funded by unrestricted research grants from Ethicon Endo-Surgery, Inc (a Johnson & Johnson company); Pfizer, Inc; and GlaxoSmithKline. The data and database development support and guidance were provided by the BCBS Association, BCBS of Tennessee, BCBS of Hawaii, BCBS of Michigan, BCBS of North Carolina, Highmark, Inc of Pennsylvania, Independence Blue Cross of Pennsylvania, Wellmark BCBS of Iowa, and Wellmark BCBS of South Dakota. All investigators had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. The authors of the abstract are responsible for its content. No statement may be construed as the official position of the Agency for Healthcare Research and Quality of the US Department of Health and Human Services.
Author Affiliations: From Department of Health Policy and Management (H-YC, JPW, TR, SNB, JBS), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD; Department of Medicine (JBS), School of Medicine, Johns Hopkins University, Baltimore, MD; Department of Epidemiology (JBS), Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
Funding Source: The Agency for Healthcare Research and Quality, Rockville, MD.
Author Disclosures: The authors (H-YC, JPW, TMR, SNB, JBS) report no relationship or financial interest with any entity that would pose a conflict of interest with the subject matter of this article.
Authorship Information: Concept and design (H-YC, TMR, JBS); acquisition of data (JPW, TMR); analysis and interpretation of data (H-YC, TMR, SNB, JBS); drafting of the manuscript (H-YC, SNB); critical revision of the manuscript for important intellectual content (JPW, SNB, JBS); statistical analysis (H-YC, TMR); obtaining funding (JPW, JBS); administrative, technical, or logistic support (TMR); and supervision (JPW, JBS).
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