Migraine

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Researchers of a recently published study used preclinical behavioral models of migraine to determine that the application of calcitonin gene-related peptide (CGRP) to the dura mater, or the protective outer layer between the skull and the brain, in mice triggers pain responses only in females.

In the United States, nearly 50 million Americans suffer from migraine, the majority of whom are between 25 to 55 years of age. The costs of treating this large population have been estimated to be $22 billion annually. A new report, published by the Pharmacy Benefit Management Institute, found that direct healthcare costs for patients with migraine were estimated at $2571 higher than those for similar patients who don’t experience migraine.

The European Headache Federation (EHF) recently sought to create an expert- and evidence-based guideline for the treatment of migraine with monoclonal antibodies that target the calcitonin gene-related peptide (CGRP). However, in reviewing available research, the EHF found that there was not enough evidence to provide a guideline based on the Grading of Recommendation, Assessment, Development, and Evaluation approach.

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