The Alzheimer's Continuum: From Silent Pathology to Clinical Progression and Treatment Timing

Alzheimer's disease is now defined biologically as well as clinically, which reveals a long silent phase. Six stages, separated by biomarkers and daily function, replace the older notion of having the disease or not.

A decade-long window before symptoms invites early intervention, much as cholesterol control prevents heart attacks. Blood biomarkers offer promise, yet false positives and unproven treatment make screening of symptom-free adults premature.