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Coverage of our peer-reviewed research and news reporting in the health care and mainstream press.

Several states should expect fewer doses next week of the Pfizer/BioNTech coronavirus disease 2019 vaccine; a new analysis finds that prescription opioid use has dropped by 60% since 2011; availability of intensive care unit (ICU) beds in Southern California reaches 0%.

For patients who are resistant to hypomethylating agent (HMA) treatment, there are no formal treatment recommendations, but several options, spanning from novel HMAs to chemotherapy, have been or are currently being studied in the setting.

Four principal themes emerged in this study, describing why Latino/a and Black transgender women and men who have sex with men discontinued their preexposure prophylaxis (PrEP) to prevent HIV.

Patient plasma samples from this study show residual circulating tumor DNA (ctDNA) correlates with a poor prognosis in women with early-stage breast cancer, explained Alexey Aleshin, MD, senior medical director of Oncology at biotech giant Natera.

After a daylong meeting, an FDA advisory panel agreed that the second vaccine in the United States to prevent coronavirus disease 2019 (COVID-19) should be put forward for use.

Physicians will soon have a more complex set of options when treating patients with multiple myeloma (MM), but the authors of a new review article argued clinicians will need to take a pragmatic approach.

NSCLC patients who developed immune-related adverse events during immunotherapy showed longer overall survival and progression-free survival than patients who did not.

A 5-phase program designed to increase knowledge among patients with heart failure has shown promise in more effective disease management and hospital readmission reduction.

Eli Lilly & Co is set to acquire Prevail Therapeutics Inc for almost $1 billion; Pfizer’s coronavirus disease 2019 vaccine vials found to contain extra doses; a new treatment has been approved for patients with advanced breast cancer.

Older adults are often at greater risk for adverse events from treatments, but they can also be excluded from randomized controlled trials (RCTs), making it difficult to know if findings are generalizable to this population.

Both clinical and physician-based factors play a role in the risk of a patient with hematologic malignancies ending up in the ICU.

There are several signs characteristic of obstructive sleep apnea (OSA) in children and adolescents, but a sleep study interpreted according to pediatric standards is the only way to properly diagnose conditions such as sleep apnea, restless leg syndrome, or primary snoring in these populations.

Although a vaccine against coronavirus disease 2019 (COVID-19) is now in the fold, Americans should expect to remain in their current work environment in the short term, with potential long-term implications spanning the next 5 years.

Samples show certain subgroups of men with prostate cancer are more receptive to radiation therapy; FDA grants emergency use authorization to an at-home coronavirus disease 2019 (COVID-19) test; Anthony Fauci, MD, says COVID-19 herd immunity is possible by spring 2021.

A new meta-analysis finds high rates of efficacy and high rates of toxicity in multiple myeloma patients treated with B-cell maturation agent (BCMA)-targeted chimeric antigen receptor (CAR)- T cells.

The panel could not reach consensus on what an expanded label might look like in an area where there are no approved therapies.

An outcomes-based agreement conducted by Boehringer Ingelheim and Highmark found that use of Jardiance (empagliflozin) among adults with type 2 diabetes (T2D) and known cardiovascular disease (CVD) was associated with a total cost of care savings of over 20%.

Visual hallucinations (VH) among patients with Parkinson disease (PD) appear to be associated with thinning of the inner retina, according to research published in Scientific Reports.

In a recently published review, researchers highlighted the disease burden of migraine, advances in preventive therapies, key takeaways from the most recent migraine management consensus statement, and advocated for increased pharmacist intervention in migraine medication management.

Kashyap Patel, MD, associate editor of Evidence-Based Oncology, a publication of The American Journal of Managed Care, will serve a 1-year term beginning in January.

FDA regulators find Moderna's experimental coronavirus disease 2019 (COVID-19) vaccine safe and effective; 27 states and the District of Columbia are asking HHS to step in regarding drug companies restricting access to 340B pharmaceuticals; pandemic worsens food insecurity in America.

In an abstract presented at CHEST 2020, investigators revealed that the emotions that patients with pulmonary arterial hypertension (PAH) regarding their illness are more complex than previously thought.

Friction of surgical instruments has the greatest association with incisional Descemet membrane detachment (DMD) during cataract surgery, according to results of a case series published in JAMA Ophthalmology.

Compared with before the Affordable Care Act (ACA), study results show there was an increase in diagnoses of early-stage breast cancer among younger vs older minority women after the act.

Results from a phase 2 trial show PXL770 yielded consistently greater responses in high-risk patients with comorbid nonalcoholic steatohepatitis (NASH) and type 2 diabetes (T2D) compared with placebo.

Stark realities exposed by the pandemic have led some to advocate for redirecting resources to have the most impact on vulnerable populations.

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AstraZeneca has agreed to acquire Alexion Pharmaceuticals for $39 billion; CDC issues coronavirus disease 2019 (COVID-19) vaccine guidance for those with a history of severe reactions to vaccines; 2.9 million COVID-19 vaccine doses began traveling this past weekend to all 50 states.

The analysis, published in Cephalalgia, found that more than 50% of patients exhibited reversion from chronic migraine to episodic migraine after week 12 of the double-blind treatment phase.