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For patients with multiple sclerosis (MS), upper extremity (UE) impairment is not uncommon, and patients with primary progressive MS tend to have a higher prevalence of UE dysfunction and greater impairment.

Patients with migraine, patent foramen ovale (PFO), and atrial septal aneurysm (ASA) have more frequent ischemic brain lesions, migraine with aura, and larger PFO sizes than patients with migraines and PFO without ASA, according to the results of a recent study.

Research and regulatory gaps in the use of marijuana will only grow unless the scientific community and policy leaders fill the void, according to a commentary series in Annals of Internal Medicine on marijuana’s rising availability.

Bristol-Meyers Squibb (BMS) and Celgene kicked off the 37th Annual JP Morgan Healthcare Conference by discussing their leading drugs, near-term launches, and early pipeline assets.

This week, companies are showcasing digital health at conferences in Las Vegas and San Francisco, but when it comes to alleviating disease burden or the cost of care for vulnerable populations, the promise of digital health is not yet fulfilled, according to a study published in Health Affairs.

Mental health advocates are lobbying Congress to help them get schizophrenia classified as a brain disease like Parkinson or Alzheimer disease, instead of as a mental illness; the annual Consumer Electronics Show, which begins this week in Las Vegas, has become an increasingly popular place for health technology firms looking for publicity in the $7 trillion global medical industry; the Trump administration warned scientists doing biomedical research at American universities that Chinese spies may be trying to steal and exploit information.

The initial trial made news because the results were at odds with ACCORD. This new analysis highlights the need for personalized diabetes care, especially among older adults.

While a common genetic mutation among patients with polycythemia vera (PV) is V617F in exon 14 of the Janus kinase 2 (JAK2) gene—which activates the tyrosine kinase—it has been reported that patients with V617F-negative PV have mutations in exon 12 of JAK2. Exon 12 mutations are involved in approximately 3% of patients with PV, and these patients often have reduced erythroblasts in the bone marrow and hypercellular bone marrow.

People living with HIV are at a greater risk for incident heart failure, with those with higher viral loads and lower CD4+ T cell counts having the greatest risk.

A recent study looking at the impact of recent exacerbations of chronic obstructive pulmonary disease (COPD) on hospitalized patients who also have coronary artery disease (CAD) found that COPD was was independently associated with additional risks of complications after percutaneous coronary intervention.

Hospitalized patients with chronic obstructive pulmonary disease (COPD) who tested positive for the flu and were unvaccinated had worse death rates and more severe illness than those who were vaccinated, according to a recent study.

Pediatric patients with early-stage Hodgkin lymphoma who are treated with chemotherapy followed by radiotherapy, known as combined modality therapy, have an improved 5-year survival rate compared with patients treated with chemotherapy alone.

A meta-analysis of 17 studies finds that botulinum toxin (Botox) is superior to placebo for the prophylactic treatment of chronic migraine.

This week, the top managed care news included a government shutdown affects healthcare; Democrats take control of the House; and The American Journal of Managed Care® names its most influential person in healthcare.

Publishing a list of conditions for which long-acting birth control is medically indicated increased uptake among women in Medicaid, but overall use remains low.

Findings in Hypertension, published by the American Heart Association, suggest a need to identify those at early risk of dementia.

Wednesday marked the start of the 116th Congress, as Democrats took charge of the House of Representatives for the first time since 2011, and the new chairman of the Energy and Commerce Committee announced 3 hearings about the Affordable Care Act (ACA), climate change, and the Trump administration’s immigration policies.

A review of thousands of FDA inspection records, recalls, warning letters, and lawsuits showed how drugs that are poorly manufactured or contaminated can reach patients; biosimilars have the potential to deliver substantial savings to the healthcare system, but only insofar as they are adopted and used in clinical practice; Maine’s new Democratic Governor, Janet Mills, ordered the state to implement Medicaid expansion with an executive order, calling for state health officials to make the necessary changes and work with the Trump administration.

January 4 marks the anniversary of the Orphan Drug Act, which was enacted in 1983. Since the law was passed, it has successfully encouraged more orphan drug development, but some now say drug makers are manipulating the system and the incentives need to be revisited.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

Hospitals that are participating in Medicare’s mandatory bundled payment model for hip and knee replacements reported a decrease in spending per episode of $812 compared with control hospitals not participating in the Comprehensive Care for Joint Replacement (CJR) program.

Patients with a history of migraine are more likely to develop spontaneous coronary artery dissection at a younger age, have depression, and post-SCAD chest pains compared with patients without a migraine history, according to the results of a recent study.

The year 2019 will finally be when the healthcare industry, particularly payers and providers, finally begins to catch up to other industries in terms of giving the consumer what they want.

A phase 1 trial by showed that decitabine with ruxolitinib was generally well tolerated and displayed promising clinical efficacy in patients with accelerated or blast-phase myeloproliferative neoplasms (MPN-AP/BP).

With everyone carrying a smartphone, there's no reason why digital health tools and apps cannot be leveraged to hold at-risk patients accountable for cardiovascular health.

As expected, California and 16 other states defending the Affordable Care Act (ACA) in a federal lawsuit announced they will appeal last month’s ruling by a Texas judge that declared the ACA unconstitutional.

Assessing the alternation of first-line antibiotics to avoid antibiotic resistance, researchers have determined that the strategy results in an increase in heterogeneity without increasing mortality.

Bristol-Myers Squibb (BMS) announced that it will be acquiring Celgene for $74 billion; Congress has confirmed the Trump administration's nominees for science advisor and drug czar; and drugmakers kicked off 2019 with drug price hikes.