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The top 5 most-listened to podcast episodes of 2021 on AJMC.com involved experts from a variety of industries that talked about some of the hot-button issues in kidney care, migraine management, and Medicare.

An 8-year journey to a chronic cough diagnosis, neurogenic cough treatment, e-cigarettes, and COVID-19 risk factors were among the most-viewed respiratory articles.

David Yeomans, PhD, associate professor of anesthesiology, perioperative, and pain medicine at Stanford University School of Medicine, explains how sodium levels can affect migraine.

An analysis of data on patients with hidradenitis suppurativa and COVID-19 found that biologic use was not associated with worse COVID-19 outcomes in this population.

In 2021, there were some changes to recommendations and an important FDA approval for patients with heart failure or who are at risk of heart disease.

Megan Olsen, MPH, principal at Avalere, discusses the role that value assessments are expected to play in the future pricing of gene and cell therapies.

Tech-driven connectivity and collaboration tools empower primary care providers (PCPs) to shepherd patient care, while simultaneously empowering patients to make more informed and strategic decisions about their own health and care journey.

The Fraser guidelines can indicate if a child is fully competent to make their own decisions, including consenting to HIV tests if they may be at risk, explained Amanda Ely, CEO of the Children’s HIV Association (CHIVA) of the United Kingdom and Ireland.

David R. Stukus, MD, FACAAI, of Nationwide Children's Hospital and The Ohio State University College of Medicine, and a board member of the American College of Allergy, Asthma & Immunology, speaks on the lack of interventions to manage the underlying causes of exacerbation in atopic dermatitis.

Articles on advances in immuno-oncology and non-small cell lung cancer were popular with readers in the past year.

Chronic liver disease is on the rise and the burden is expected to increase in the future, both in the United States and around the world. These are the most-read articles about liver disease in 2021.

The new recommendations for systemic lupus erythematosus (SLE) use disease activity index scores and evaluator’s global assessment measures, but they do not include serology.

James Auran, MD, a professor of ophthalmology at Columbia University Irving Medical Center and president of the American Society of Ophthalmic Trauma, discusses how a lack of providers has created a crisis in the United States.

Psoriasis severity and treatment outcomes were found to differ across US geographic regions, in which the East South Central and West South Central regions were associated with the greatest frequencies of very severe disease burden and decreased likelihood of achieving targeted response within 6 months of initiating biologic therapy.

The most-read AJAC papers of 2021 analyze real-world programs to transform health care and provide insight into physician perspectives of health care and insurance.

An analysis uncovered racial, ethnic, and socioeconomic inequities regarding access to glucagon-like peptide-1 receptor agonists among US patients with diabetes.

This year's most-read inflammation articles included ones about Janus kinase inhibitors and the impact of biologics or systemic corticosteroids on severe COVID-19.

This year’s most-read articles on Fabry disease touched on advancements in therapy, health risks of the disease, and keys to improved diagnosis.

With legalization of cannabis across much of the United States and all of Canada, Don Sin, MD, FRCP, MPH, a professor of respiratory medicine at the University of British Columbia and head of the Centre of Heart Lung Innovation, St. Paul’s Hospital, has concerns about the effect of wider cannabis usage on chronic obstructive pulmonary disease (COPD) in future decades.

Data from the GLOW study of minimal residual disease evaluation following chemotherapy for chronic lymphocytic leukemia (CLL) show the kinase inhibitor/B-cell lymphoma-2 inhibitor pair produced superior outcomes compared with the alkylating agent/monoclonal antibody combination.

Results of a meta-analysis and systematic review indicate rosacea is significantly associated with depression and anxiety.

This year's most-read migraine articles covered a range of topics, such as new causes of migraine, its link to bipolar disorder, and COVID-19's impact on existing migraine.

Behavioral cough therapy should be used as early intervention, said Laurie Slovarp, PhD, CCC-SLP, associate professor in the School of Speech, Language, Hearing, and Occupational Sciences at University of Montana.

Despite being the seventh adalimumab biosimilar approved in the United States, there are none on the market yet.

Readers were most interested in articles about cost of therapy, drug efficacy, and a unique case related to COVID-19.

Michael Thorpy, MD, director, Sleep-Wake Disorders Center, Montefiore, and professor of neurology, Albert Einstein College of Medicine, discusses treatment implications for clinicians managing chronic insomnia and potential comorbid conditions.

Marijuana use by people with HIV during pregnancy and post partum increased over time, with the prevalence of general substance use increasing more post partum.

Epigenetics has a role in choosing the right medicine in lung cancer, artificial intelligence can predict outcomes in a highly aggressive cancer, and more.