May 13th 2024
Immune checkpoint blockade therapy works by preventing the binding of checkpoint and partner proteins, thereby allowing T cells to continue their work of attacking and killing cancer cells.
Disease-Modifying Antirheumatic Drugs Linked to Decreased Risk for Autoimmune Thyroid Disease
November 28th 2023A nationwide cohort study linked biologic disease-modifying antirheumatic drugs with decreased risks for the onset of autoimmune thyroid disease in patients with rheumatoid arthritis.
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Gene Therapy Success in UK Likely Depends on Overcoming Education, Psychological Support Challenges
November 27th 2023Education, psychological support, and implementation guidance are the top unmet needs identified by investigators from the United Kingdom concerning gene therapy use for hemophilia.
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Dr Jeffrey Sippel: Medicare Advantage NIV Denials Take Time From Patients With ALS
November 24th 2023Jeffrey Sippel, MD, MPH, addresses the increasing denial of insurance claims for non-invasive ventilators (NIV) in Medicare Advantage plans, particularly impacting ALS patients, emphasizing the time crunch on patients, and criticizing the financial focus over patients' well-being.
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Network Meta-Analysis Validates the Use of Methotrexate in RA Compared With Other Treatments
November 24th 2023A network meta-analysis confirmed the efficacy of methotrexate for patients with rheumatoid arthritis (RA) and validated it as the primary reference conventional synthetic disease-modifying antirheumatic drug for treatment in this population.
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Upadacitinib Demonstrates Efficacy in RA Treatment Regardless of Patient’s Baseline CRP Levels
November 22nd 2023In a real-world, prospective study, upadacitinib demonstrated great potential for the treatment of rheumatoid arthritis (RA) regardless of a patient’s baseline C-reactive protein (CRP) levels.
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Allegations call out restrictions on medically necessary care; CDC data highlight surge in COVID-19 deaths and hospitalizations; failure to include additional Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) aid raises concerns over food access.
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AAD Updates Guidelines for AD Treatment Using Phototherapy, Systemic Therapies
November 21st 2023These new atopic dermatitis (AD) treatment guidelines from the American Academy of Dermatology (AAD) update their 2014 recommendations for the management of AD with phototherapy and systemic therapies.
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RHC Still Recommended Over Echocardiography for Detecting COPD-PH
November 20th 2023In a single-center, retrospective analysis, echocardiography demonstrated low sensitivity but high specificity for diagnosing pulmonary hypertension (PH) in advanced chronic obstructive pulmonary disease (COPD).
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What We’re Reading: Rising Flu Cases; RSV Drug Shortage; Forever Chemical Restrictions
November 20th 2023Health officials said that at least 7 states reported high levels of illness, with cases also rising in other parts of the country; a group of Senate Democrats demanded answers about the shortage of nirsevimab, a new respiratory syncytial virus (RSV) drug; Pentagon officials told Congress that eliminating per- and polyfluorinated substances would undermine military readiness.
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Advancements Needed in Research on SCD-Associated Pulmonary Hypertension
November 18th 2023To stress the importance of considering pulmonary complications in sickle cell disease (SCD), researchers compiled an overview on the state of research and available treatment options for patients with SCD associated with pulmonary hypertension.
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Telitacicept Efficacious, Safe in Treating Patients With RA, Inadequate MTX Response
November 18th 2023In these phase 3 findings presented at ACR 2023, the safety and efficacy of this drug was proven in American College of Rheumatology-20 (ACR20), ACR50, and Disease Activity Score in 28 joints with Erythrocyte Sedimentation Rate responses.
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Researchers Identify Potential Biomarkers for SMA Motor Improvement Following Nusinersen Treatment
November 17th 2023A retrospective, exploratory analysis identifies biomarkers predictive of spinal muscular atrophy (SMA) response to nusinersen and suggests the efficacy of using machine learning algorithms to anticipate patient outcomes.
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Alyson Moadel-Robblee, PhD, deputy director of community engagement and cancer health equity at Montefiore Einstein Comprehensive Cancer Center, discussed the center's evolving patient distress screening process and the Bronx Oncology Living Daily support program for patients with cancer.
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Data on Delandistrogene Moxeparvovec Can Inform Future Gene Therapies
November 17th 2023The FDA approved delandistrogene moxeparvovec-rokl (Elevidys, Sarepta Therapeutics) in June to treat Duchenne muscular dystrophy in ambulatory pediatric patients aged 4 through 5 who have a confirmed DMD gene mutation.
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Dr Jeffrey Sippel: The Impact of Insurance Denials for Patients With ALS
November 16th 2023Due to the frequent rejection of claims for noninvasive ventilators by Medicare Advantage plans, individuals with amyotrophic lateral sclerosis (ALS) are experiencing disproportionately high rates of hospital admissions.
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