• Center on Health Equity and Access
  • Clinical
  • Health Care Cost
  • Health Care Delivery
  • Insurance
  • Policy
  • Technology
  • Value-Based Care

Bevacizumab Proves Effective in Combination With Chemotherapy in Platinum-Resistant Ovarian Cancer

Article

The AURELIA trial comparing the efficacy of bevacizumab plus chemotherapy, versus chemotherapy alone, presented encouraging results in platinum-resistant ovarian cancer patients.

An editorial published in the latest issue of the Journal of Clinical Oncology highlights the encouraging results reported by the AURELIA trial, a randomized trial comparing the effectiveness of chemotherapy (investigator’s choice of once-per-week paclitaxel, pegylated liposomal doxorubicin, or topotecan) combined with bevacizumab in recurrent platinum-resistant ovarian cancer. A companion article in the same issue reports patient-related outcomes (PROs) in AURELIA, evaluating abdominal/GI PROs in the patients.

Reflecting the results reported by previous trials that studied bevacizumab (GOG, ICON7 and OCEANS), AURELIA observed a statistically significant benefit in progression-free survival (PFS) by including bevacizumab in the chemotherapy regimen. A significant improvement (3.3 months) in median PFS was observed, with the patients in the bevacizumab plus chemotherapy arm presenting a median survival of 6.7 months (hazard ratio, 0.48; 95% confidence interval 0.38 to 0.60; P <0.001) compared to a median survival of 3.3 months observed in patients receiving chemotherapy alone. Further, similar to the OCEANS trial, overall response rate (OSS) significantly improved from 11.8% to 27.3% (P = 0.001) in the bevacizumab plus chemotherapy arm in the AURELIA trial, as assessed by the RECIST criteria.

Read the complete editorial here: http://bit.ly/1fevs2JSource: Journal of Clinical Oncology; Published online March 17, 2014

Related Videos
Mila Felder, MD, FACEP, emergency physician and vice president for Well-Being for All Teammates, Advocate Health
Will Shapiro, vice president of data science, Flatiron Health
Mila Felder, MD, FACEP, emergency physician and vice president for Well-Being for All Teammates, Advocate Health
Mila Felder, MD, FACEP, emergency physician and vice president for Well-Being for All Teammates, Advocate Health
Will Shapiro, vice president of data science, Flatiron Health
Jonathan E. Levitt, Esq, Frier Levitt, LLC
Judy Alberto, MHA, RPh, BCOP, Community Oncology Alliance
Mila Felder, MD, FACEP, emergency physician and vice president for Well-Being for All Teammates, Advocate Health
Emily Touloukian, DO, Coastal Cancer Center
Will Shapiro
Related Content
© 2024 MJH Life Sciences
AJMC®
All rights reserved.