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Can the 4 Ps Devise Interventions to Reduce the Financial Toxicity of Cancer?

Publication
Article
Evidence-Based OncologyJuly 2017
Volume 23
Issue SP8

A discussion at the 2017 American Society of Clinical Oncology Annual Meeting addressed practical solutions to address the financial toxicity of cancer care and identified leads for future intervention studies aimed to prevent or reduce this burden.

THERE IS NO ARGUING

that cancer care can drain an individual’s or a family’s coffers. A discussion at the 2017 American Society of Clinical Oncology Annual Meeting addressed practical solutions to address the financial toxicity of cancer care and identified leads for future intervention studies aimed to prevent or reduce this burden.

The session, chaired by Yousuf Zafar, MD, MHS, associate professor of medicine, Duke University Medical Center, included the 4 Ps:

  • Pharma: Matthew Shaulis, president, North America Oncology, Pfizer
  • Payer: Lee N. Newcomer, MD, senior vice president, Oncology and Genetics, UnitedHealth Group
  • Physician: Leonard Saltz, MD, chief, Gastrointestinal Oncology Service and head of the Colorectal Oncology Section, Memorial Sloan Kettering Cancer Center
  • Patient: Shelley Fuld Nasso, MPP, chief executive officer, National Coalition for Cancer Survivorship.

Zafar asked the panelists to provide their 1 clear solution to the problem of financial toxicity in oncology—without using slides. Shaulis said that Pfizer shares the goal of improving quality of care for patients. “We need to focus and prioritize. We have to tailor market-based solutions to ensure continued innovation.”

A longitudinal actuarial study conducted among cancer patients by Milliman and sponsored by Pfizer identified a 500% increase in care costs in the first month of care, mainly due to diagnosis and initial treatment, Shaulis told the audience.1 The costs were highest for colorectal cancer and lung cancer, followed by breast cancer. “However, consistent across the numerous studies was that cancer drugs accounted for only 20% of the total cost of care.”

From a more holistic perspective, we also should include peripheral costs, such as loss of work for the patient and caregivers, Shaulis added. “Market-based solutions are important because innovation and choice are necessary to ensure support for new medications,” he added, and competition paves the path to affordable access, investment in data, and novel reimbursement mechanisms.

“As a federal or commercial insurance program, you are mandated to provide coverage to all FDA-approved drugs. So, I propose ending the mandate for providing coverage for each and every drug that is out there even if it does not provide value,” said Newcomer, the payer voice in the discussion. “When you make a value decision, you are using a set of principles that others may not agree with,” he said. “But with the mandate on cancer drugs, we cannot use the value quotient.”

Newcomer referenced a retrospective study by UnitedHealth Group that was presented at the meeting using data from stage 4 patients with metastatic non—small cell lung cancer (mNSCLC).2 The study found that patients treated with the 5 most commonly prescribed first-line therapies for mNSCLC have much shorter durations of therapies (52-76 days) than reported in published clinical trials, with a significant risk of hospitalization (18% to 30%) and at substantial cost ($34,971 to $108,100).

“This is an easy value decision to make, but the mandate creates a barrier,” Newcomer said. He concluded that when there’s competition among multiple regimens that give us the same results, we need to have the flexibility to make those value decisions.

“For me as an oncologist, my 1 solution is to know the cost of the treatment,” said Saltz. “What we need is an informed discussion among stakeholders, and for that, we need everyone to have all the information.’ He emphasized that he was talking about cost, not “value.” Saltz believes that cost and value are not the same. “They are related. They are inversely proportional.”

However, we cannot put a number on value, and we cannot provide an accurate qualitative context to it. Saltz drove home the point that while physicians consider it their duty to provide patients an accurate estimate of toxicities and the adverse effects, discussions of the impact on patient finances “is also a part of our job. We cannot be uncomfortable about this. I’d also argue that as academicians, we could be considering costs in our trials. When we look at benefits (such as overall survival and disease-free survival), we could also include cost in the equation.”

Nasso said that patients want to live their life well during and after treatment. They want to be functional, working, and understand the impact on their families during treatment. “So, the burden of finances needs to be a part of the overall impact on the patient, in addition to the disease being treated,” she said.

Care planning, Nasso believes, should not be a checkbox; it should be a conduit to initiate a discussion on the topic. This should include conversations around out-of-pocket costs as well as the indirect cost of the treatment: hospital visits, work loss for self and family, etc. “Affordability should not be on the map at all, but that’s where we currently are.”

She emphasized the importance of a cancer care plan for the patient to revisit after their conversation with the care provider and added that the healthcare system should reimburse this process through incentives. She also urged physicians to step up and be more proactive on this front. “I’d like to see a system where we can help patients go through this process.”REFERENCES

1. Dieguez G, Ferro C, Pyenson BS. A multi-year look at the cost burden of cancer care. Milliman website. milliman. com/uploadedFiles/insight/2017/cost-burden-cancer-care.pdf. Published April 11, 2017. Accessed June 6, 2017.

2. Newcomer LN, DaCosta Byfield S, Chastek B, Korrer S, Horstman T, Malin J. Describing the value of the most common first line NSCLC regimens in a real-world setting. J Clin Oncol. 2017;35(suppl; abstract 9046).

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