Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer, according to researchers.
hronic inflammation in benign prostate tissue is associated with high-grade prostate cancer, according to researchers.
However, Dr. Elizabeth A. Platz told Reuters Health by email, "We don't anticipate direct clinical implications of our work. The prevalence of inflammation in the prostate was so high -- even in the controls (comparison men without a diagnosis of cancer) -- that the mere presence of inflammation could not be used as a tool to identify men at risk for this cancer."
"We performed the work to learn more about the etiology of prostate cancer, especially aggressive disease," added Dr. Platz, of Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
As reported April 18th online in Cancer Epidemiology Biomarkers & Prevention, Dr. Platz and colleagues conducted a case-control study nested in the placebo arm of a large cancer prevention trial. At enrollment, the men were at least 55 years old and had a normal digital rectal examination and a serum prostate-specific antigen (PSA) level of 3 ng/mL or less.
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