We have a number of biomarkers that we have shown are associated with a better response to certain new therapies, said Oliver Dorigo, MD, PhD, associate professor, obstetrics and gynecology, Stanford University Medical Center.
We have a number of biomarkers that we have shown are associated with a better response to certain new therapies, said Oliver Dorigo, MD, PhD, associate professor, obstetrics and gynecology, Stanford University Medical Center.
Transcript
What biomarkers have you identified to determine prognosis and treatment outcomes in gynecologic malignancies?
We have a number of biomarkers that we have shown are associated with a better response to certain new therapies. PARP inhibitors, for example, work the best in those patients that have either germline mutations of BRCA1 and BRCA2 or those mutations only in the tumor tissue. It’s particularly true in ovarian cancer, where we have the most experience.
We also know that certain ovarian cancers have a certain degree of defects and repair mechanisms that the cell uses to repair DNA damage. If these mechanisms are dysfunctional, then patients, again, are more likely to respond to PARP inhibitors. We call this a so-called homologous recombination deficiency score, which is a measure or a biomarker that predicts the response to PARP inhibitors, at least to some extent.
In immunotherapy, biomarkers relate mostly to what we call microsatellite instability, which does increase the probability of a patient responding to immune-checkpoint inhibition.
The Importance of Examining and Preventing Atrial Fibrillation
August 29th 2023At this year’s American Society for Preventive Cardiology Congress on CVD Prevention, Emelia J. Benjamin, MD, ScM, delivered the Honorary Fellow Award Lecture, “The Imperative to Focus on the Prevention of Atrial Fibrillation,” as the recipient of this year’s Honorary Fellow of the American Society for Preventive Cardiology award.
Listen
IQVIA Report Spotlights Shortages for Pain, Obesity, and Oncology Therapies
November 21st 2023A new report from IQVIA provides an overview of current US drug shortages, shedding light on major areas of concern, such as medications to address pain, cardiovascular conditions, obesity and diabetes, and multiple forms of cancer.
Read More