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Episode 2 - Variability in Disease Course and Treatment Approach
Because each patient with castration-resistant prostate cancer (CRPC) experiences a different disease course, clinicians need to evaluate several factors when making treatment decisions, explains Christopher Sweeney, MBBS.
As an example, Dr Sweeney describes 2 patient cases and discusses the criteria he uses to determine whether to recommend hormonal therapy (eg, with agents such as abiraterone or enzalutamide) or nonhormonal therapy (ie, chemotherapy).
Based on the variability of disease course in patients with CRPC, research on tumor heterogeneity is being conducted. An area that is currently being investigated is a variation in the androgen receptor that allows tumor cells to grow despite testosterone blockade and androgen receptor blockade. Dr Sweeney remarks that this variation of the androgen receptor holds promise as a biomarker to help determine whether or not a patient would respond to hormonal therapy.
Watch our related Peer Exchange, Oncology Stakeholder Summit 2014: Evidence-Based Decisions to Improve Quality and Regulate Costs
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April 25th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the April 2024 issue of The American Journal of Managed Care® about their findings on the rates of low-value cancer care services throughout the COVID-19 pandemic.
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Oncology Onward: A Conversation With Penn Medicine's Dr Justin Bekelman
December 19th 2023Justin Bekelman, MD, director of the Penn Center for Cancer Care Innovation, sat with our hosts Emeline Aviki, MD, MBA, and Stephen Schleicher, MD, MBA, for our final episode of 2023 to discuss the importance of collaboration between academic medicine and community oncology and testing innovative cancer care delivery in these settings.
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Trastuzumab Deruxtecan Receives FDA Approval for HER2-Positive Solid Tumors
April 5th 2024FDA granted accelerated approval to trastuzumab deruxtecan-nxki for adult patients with unresectable or metastatic HER2-positive solid tumors who received prior systemic treatment and have no satisfactory alternative treatment options.
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