The UCSF study identified a window of 30 to 35 days post surgery, following surgery in patients with glioblastoma multiforme, when delayed radiation significantly improved OS and PFS.
Patients with newly diagnosed (GBM) have significantly better overall survival when there is a short delay between surgery and the start of radiation therapy, investigators say.
The optimal time to start radiation in patients with GBM is controversial, with some studies showing worse outcomes among patients for whom therapy is delayed and others suggesting that a short delay may not be harmful or may even be beneficial, said Seunggu Han, MD, a neurosurgery resident at the University of California San Francisco (UCSF), at the Congress of Neurological Surgeons (CNS) 2014 Annual Meeting here.
"With most other malignancies — , lung cancer — it's very clear that even if you delay radiation a little bit, outcomes are significantly worse, but it's beginning to look like it's not quite the same for glioblastoma," he said in an interview with Medscape Medical News.
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