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In The Literature: Ramucirumab Improves OS in Advanced Gastric Cancer Patients
The study, published in Lancet Oncology, found that ramucirumab significantly improved survival by over 2 months.
A randomized, placebo-controlled, double-blind, phase 3 trial in advanced gastric cancer patients, compared ramucirumab (Cymraza) plus paclitaxel with placebo plus pacitaxel. The global phase 3 study, conducted in 170 centers across 27 countries in 4 continents, found ramucirumab, a VEGFR-2 antagonist antibody, improved survival by more than 2 months when combined with paclitaxel, compared with the placebo arm. Of the 665 patients aged 18 years or older, 330 were in the ramucirumab arm and 335 were in the placebo arm. Grade 3 or higher adverse events observed in the treatment arm included neutropenia, leucopenia, hypertension, fatigue, anaemia, and abdominal pain.
Trial number on ClinicalTrials.gov: NCT01170663
Link to the paper published in Lancet Oncology: http://bit.ly/1uJN54N
Oncology Onward: A Conversation With Penn Medicine's Dr Justin Bekelman
December 19th 2023Justin Bekelman, MD, director of the Penn Center for Cancer Care Innovation, sat with our hosts Emeline Aviki, MD, MBA, and Stephen Schleicher, MD, MBA, for our final episode of 2023 to discuss the importance of collaboration between academic medicine and community oncology and testing innovative cancer care delivery in these settings.
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