Literature: Germline BRCA Mutations Increase Susceptibility to Salivary Gland Cancer

The study, published online in JAMA Otolaryngology - Head & Neck Surgery, found a significant increase in the rate of head and neck cancers in individuals carrying a BRCA mutation.

5754 individuals from 187 pedigrees were included in the cohort. Previous research has identified a link between salivary gland cancer and breast cancer, which formed the basis of the current study.

From the 5754 individual cohort, 2 parotid gland cancers, 2 salivary gland cancers not otherwise specified, and 1 adenoid cystic carcinoma were identified.





One of these cancers likely did not segregate with the mutation, and another individual tested negative for the mutation, resulting in a rate of 3 of 5754 (0.052%). The observed rate of 3 of 5754 cases (0.052%) of head and neck cancers in -positive probands and likely carriers is significantly higher than the background incidence rate of 3 of 100,000 (0.003%) per year (&thinsp;<&thinsp;.001).

The Clinical Cancer Genetics Program at The Ohio State University Wexner Medical Center. A total of

In this retrospective review, the authors evaluated several pedigrees of patients who were diagnosed with breast cancer in

Link to the journal article:

Link to Rebecca Nagy's (senior author on the paper) participation in AJMC's panel discussion on genetic counseling: