Opinion|Videos|March 31, 2025

Lp(a) Levels: A Continuous Relationship With ASCVD Levels and Consistent Throughout a Lifetime

Experts discuss the evidence supporting the continuous relationship between lipoprotein(a) (Lp[a]) levels and atherosclerotic cardiovascular disease (ASCVD), as recognized by the National Lipid Association, and explore how Lp(a) levels may change throughout a person’s lifetime or in response to lifestyle factors.

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Video content above is prompted by the following:

  • Historically, Lp(a) levels of at least 125 nmol/L (or 50 mg/dL) have been considered elevated. However, the National Lipid Association—or NLA—now recognizes the relationship between Lp(a) and ASCVD to be continuous. Could you speak to the evidence supporting this conclusion?
  • How, if at all, do Lp(a) levels change throughout a person’s lifetime or in response to lifestyle factors?

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