The research headed by Roger Gomis at IRB Barcelona, with the collaboration of Joan MassaguÃ©, describes that the loss of the suppressor RARRES3 promotes the colonization of breast cancer cells in the lung.
A study published today in EMBO Molecular Medicine reveals that the loss of function of the gene RARRES3 in breast cancer cells promotes metastasis to the lung.
The research, headed by Roger Gomis, ICREA Professor at the Institute for Research in Biomedicine (IRB Barcelona), is the result of a collaboration between two IRB labs and Joan Massagué, at the Memorial Sloan Kettering Cancer Center in New York.
The scientists demonstrate that RARRES3 is suppressed in estrogen receptor-negative (ER-) breast cancer tumours, thus stimulating the later invasion of the cancer cells and conferring them “a greater malignant capacity,” says Gomis, head of the Growth control and cancer metastasis lab at the IRB.
Press release: http://bit.ly/1hBARSK
Source: IRB Barcelona