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Nintedanib Demonstrates Promise in LUME-Lung-1 Trial in Patients With Advanced or Recurrent NSCLC
A new oral angiogenesis inhibitor for the treatment of lung cancer could be edging closer to the market: Approval application for nintedanib (Boehringer Ingelheim) has been filed in Europe and is being prepared for the United States.
A new oral angiogenesis inhibitor for the treatment of lung cancer could be edging closer to the market: Approval application for nintedanib (Boehringer Ingelheim) has been filed in Europe and is being prepared for the United States.
The data for nintedanib come from the phase 3 trial known as LUME-Lung-1, recently published in the Lancet Oncology.
The data were also presented in a poster and discussed here at the European Lung Cancer Conference (ELCC) 2014 by principal investigator, Martin Reck, MD, PhD, head of thoracic oncology at the Lungen Clinic, Grosshansdorf, Germany.
The trial was conducted in 1314 previously treated patients with stage 3B or 4 or recurrent non-small cell lung cancer (NSCLC), who were given docetaxel as second-line therapy. Adding nintedanib significantly improved the progression-free survival to 3.4 months vs 2.7 months with docetaxel alone (hazard ratio [HR], 0.79; P = .0019).
The improvement in overall survival (OS) for all participants did not reach significance (10.1 vs 9.1 months; P = .27).
Read the complete news here:
Source: Medscape
Oncology Onward: A Conversation With Penn Medicine's Dr Justin Bekelman
December 19th 2023Justin Bekelman, MD, director of the Penn Center for Cancer Care Innovation, sat with our hosts Emeline Aviki, MD, MBA, and Stephen Schleicher, MD, MBA, for our final episode of 2023 to discuss the importance of collaboration between academic medicine and community oncology and testing innovative cancer care delivery in these settings.
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Trastuzumab Deruxtecan Receives FDA Approval for HER2-Positive Solid Tumors
April 5th 2024FDA granted accelerated approval to trastuzumab deruxtecan-nxki for adult patients with unresectable or metastatic HER2-positive solid tumors who received prior systemic treatment and have no satisfactory alternative treatment options.
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