Opdivo Plus Chemo Boosts Progression-Free Survival 26% Over Chemo Alone in Late-Stage NSCLC
Researchers are examining combination therapies with immunotherapy, with and without chemotherapy.
Combination treatments involving checkpoint inhibitors continue to gain attention, including both combinations involving more than 1 immunotherapy and those that involve immunotherapy and chemotherapy. Researchers continue to seek biomarkers that will allow them to match treatment combinations with patients who will most benefit.
On Monday, Bristol-Myers Squibb followed up on results it released earlier this year from the phase 3 Checkmate 227 trial in non-small cell lung cancer (NSCLC); it previously
Results presented at the American Society of Clinical Oncology (ASCO) involve patients in the trial arm treated with nivolumab and chemotherapy. Researchers report results for 550 chemotherapy-naïve patients with stage IV or recurrent NSCLC; they had no known EGFR/ALK mutations, and had < 1% PD-L1 expression. These included 177 in the nivolumab plus chemotherapy arm, compared with 186 who were treated with chemotherapy only.
Those taking the nivolumab-chemotherapy arm had improved progression-free survival (PFS) over the chemotherapy arm (hazard ratio = 0.74; CI, 0.58-0.94). Minimum follow-up was 11.2 months, and patients were treated up to 2 years. Most subgroups saw PFS with the nivolumab-chemotherapy combination, but the benefit was more pronounced among non-squamous (HR = 0.68) than among squamous (HR = 0.92).
The rates of adverse events that caused patients to stop taking therapy were about the same in both the nivolumab-chemotherapy arm (13%) and the chemotherapy arm (14%).
Reference
Borghaei H, Hellman MD, Paz-Ares LG, et al. Nivolumab + platinum doublet chemotherapy vs chemo as first-line treatment for advanced non-small cell lung cancer (NSCLC) with < 1% tumor PD-L1 expression. J Clin Oncol 2018; 36 (suppl; abstr 9001).
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