
PAD2 Overexpression May Promote Skin Cancer
Research published this month in the journal Cancer Research, found that increased expression of the enzyme PAD2 in young mice could lead to skin tumors that could progress to invasive squamous cell carcinoma.
New research on an enzyme linked to cancer development shows that 37% of mice that produce excessive quantities of the enzyme developed skin tumors within 4 to 12 months of birth, and many of these growths progressed to highly invasive squamous cell carcinoma, a common form of skin cancer.
Cancer Research
This finding, published online September 11 in the journal , provides the first genetic link between the activity of the enzyme, called PAD2, and
Lead author Scott Coonrod, the Judy Wilpon Associate Professor of Cancer Biology at the Baker Institute for Animal Health in Cornell's College of Veterinary Medicine, has studied links between PAD2 and other PAD (peptidylarginine deiminase) enzymes and
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