Michael Kolodziej, MD: The question about how responsive pathways are to the best available evidence, I think, is largely unfounded. In all the years that we managed pathways, we did have occasions where we had updated pathways, regretted it, and had to go back. We never got accused of not being prompt enough, and that’s because we had a structure whereby really game-altering therapies, either presented at a national meeting or more typically published in peer-reviewed literature, would be reflected in the pathways in a very timely fashion. So, people weren’t getting cheated out of access to something that was really going to save their lives.
I think implicit in the question of timeliness is a subtext that physicians should be able to act on “a good idea”, preliminary evidence. And I will say that maybe when I started in oncology, when drugs were very inexpensive and there were few options, what was true then and what is true now is that the therapies are very, very expensive, and speculative prescribing, irrespective of pathways, is something that payers are simply not going to allow. So, what’s the solution? Let’s fix the clinical trials mechanism so that we can get those patients on a trial and they would make a decision very quickly about whether that’s a good idea or a bad idea. This is not the payer’s problem. There’s a lot of really great stuff out there, and I know there’s a great deal of enthusiasm for combining it, so let’s answer the question about whether it makes sense or not.
As we consider the consequences of what I’ve called speculative prescribing, we actually face the same potential costs that we discussed a while ago, which is, number one, its cost of therapy, but number two, its human cost or toxicity cost. Now, you can look at that as human suffering from side effects, or you can look at it as unnecessary spending on inpatient or ICU use. It’s kind of interesting. There’s this impression that somehow immunotherapy is much less toxic than chemotherapy. That may, in fact, prove to be the case.
But, I was recently on a panel with an academic physician from the Northeast, and she said that the current inpatient service at her institution is almost exclusively people hospitalized with immunotherapy toxicity. That’s a very telling statement. There is no question that if you add nivolumab to ipilimumab in melanoma, you increase the toxicity a ton. That’s not arguable. There are costs associated with that. So, I think the health plan, and, honestly, all oncologists should be concerned about that. Is the price, and I use that term in its greatest sense, worth it? Well, we have to find that out.
An Overview of Health Care and Pharmaceutical Trends, 2023-2024
April 19th 2024Douglas M. Long, BA, MBA, was featured as the keynote speaker on the closing day of The Academy of Managed Care Pharmacy 2024 annual meeting, with a session dedicated to surveying the health care and pharmaceutical trends of the last year.
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Navigating Health Literacy, Social Determinants, and Discrimination in National Health Plans
February 13th 2024On this episode of Managed Care Cast, we're talking with the authors of a study published in the February 2024 issue of The American Journal of Managed Care® about their findings on how health plans can screen for health literacy, social determinants of health, and perceived health care discrimination.
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Government agencies have created an online portal for the public to report potential anticompetitive practices in health care; there are changes coming to the “boxed warning” section for chimeric antigen receptor T-cell therapies (CAR T) to highlight T-cell blood cancer risk; questions about the safety of obesity medications during pregnancy have arisen in women on them who previously struggled with fertility issues.
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Drs Raymond Thertulien, Joseph Mikhael on Racial Disparities in Multiple Myeloma Care Access
December 28th 2023In the wake of the 2023 American Society of Hematology Annual Meeting and Exposition, Raymond Thertulien, MD, PhD, of Novant Health, and Joseph Mikhael, MD, MEd, FRCPC, FACP, chief medical officer of the International Myeloma Foundation, discussed health equity research highlights from the meeting and drivers of racial disparities in multiple myeloma outcomes.
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Gene, Light Therapy Combo Shows Promise Against Prostate Cancer Cells in Proof-of-Concept Study
April 18th 2024In their preclinical model, the researchers found efficacy both in vitro and in vivo by using CRISPR-Cas9 to mimic porphyria and combining the technology with light therapy.
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