Peripheral T-cell lymphomas affect the lymphatic system and can appear throughout the body, causing symptoms that include swollen lymph nodes, an enlarged spleen, fever, and unexplained weight loss.
Real-World Study Finds Brentuximab Vedotin With Chemo Is Safe, Effective in First-line Treatment of PTCL
Brentuximab vedotin combined with cyclophosphamide, doxorubicin, and prednisone (CHP) shows promising results as a first-line treatment in newly diagnosed peripheral T-cell lymphoma (PTCL).
Brentuximab vedotin (BV; Adcetris; Pfizer) alongside a combination of cyclophosphamide, doxorubicin, and prednisone (CHP) was safe and effective when used as the first treatment for patients newly diagnosed with peripheral T-cell lymphoma (PTCL), a rare and aggressive form of
The 50 patients in this small, real-world study received treatment between January 2021 and October 2023, according to authors publishing in Annals of Hematology.1
PTCLs are not a single type of cancer, but a group of fast-growing NHL subtypes affecting less than 15% of all adults with a form of NHL. According to the
Data
Other strategies include CHOP, which adds vincristine (Oncovin) to CHP, or a 5-drug regimen that also includes etoposide. BV is typically used in combination with a chemotherapy regimen in the first line, IQVIA reported.2
For this new study, investigators retrospectively analyzed clinical data from patients with PTCL who received BV in combination with a CHP-like regimen during the study period. Median age of the patients was 57 years (range, 22-86). Results showed the following1:
- Median number of BV cycles administered was 6 (range, 2-8)
- After a median follow-up of 35.2 months (95% CI, 30.9-39.5), the overall response rate was 80%, with 44% of the patients achieving a complete response (CR)
- Patients with a subtype of ALK-positive anaplastic large cell lymphoma had a CR rate of 70.6%
- Median progression-free survival was 39.7 months (95% CI, 14.7-NA), while the median overall survival (OS) was not reached (the 1-year OS rate, 90%)
Bone marrow infiltration at diagnosis was the sole factor that contributed to poor OS. As for adverse events, neutropenia was most common, seen in 81.3% of patients, while peripheral neuropathy was seen in 16.7%.
“This real-world study suggests that BV combined with a CHP-like regimen is an effective and safe first-line treatment for patients with newly diagnosed PTCL,” the authors concluded.1
References
- Guan F, Zhang Y, Guo X, et al. Brentuximab vedotin plus CHP-like regimen for the first-line treatment of PTCL patients: a real-world single center study. Ann Hematol. Published online July 22, 2025. doi:10.1007/s00277-025-06507-7
- Dharmani C, Unni S, Pham N, et al. Real-world treatment patterns, healthcare resource utilization and costs among patients with peripheral T-cell lymphoma. Future Oncol. 2024;20(15):1013-1030. doi:10.2217/fon-2023-0615
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