Opinion|Videos|September 24, 2024

Role of MRAs in HFmrEF and HFpEF

Javed Butler, MD, MPH, MBA, discusses the current mineralocorticoid receptor antagonists (MRAs) used for heart failure (HF) with midrange ejection fraction (EF) and HF with preserved EF, emphasizing the role of nonsteroidal MRAs such as finerenone, and explore how the FINEARTS-HF results could translate into real-world benefits and inform the clinical pathway for these patients.

Video content above is prompted by the following:

  • Which mineralocorticoid receptor antagonists (MRAs; ie, steroidal, nonsteroidal) are currently indicated or used for treating heart failure with midrange ejection fraction (HFmrEF) and HF failure with preserved EF (HFpEF), and what role does a nonsteroidal MRA such as finerenone have to offer in this treatment landscape based on the results of FINEARTS-HF?
  • How might these results translate into real-world benefit, and where do you see their place in the clinical pathway for patients with HFmrEF or HFpEF?

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