Major Depressive Disorder

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Reassessing Antidepressant Efficacy: A Meta-Analysis of Control Group Outcomes in SSRI, Psilocybin, and Esketamine Trials

By Alana Hippensteele, MA

July 31st 2025

A meta-analysis showed that control group outcomes in psilocybin trials for depression were significantly weaker than those in selective serotonin reuptake inhibitor (SSRI) and esketamine trials, suggesting that psilocybin’s large observed treatment effects may be inflated by methodological factors such as functional unblinding and expectancy bias.

Hands psychology and mental health with a woman in a therapy session for grief counseling after loss Anxiety stress or depression with a female patient feeling nervous in a clinic for support-KApeopleimages-stock.adobe.com.jpeg

Adults With Depression Likely Develop Physical Conditions 30% Faster

By Giuliana Grossi

February 13th 2025

Significant Clinician-Level Differences Exist in Antidepressant Prescribing Patterns, Outcomes

By Giuliana Grossi

July 10th 2024

Improving Access to Alternative Therapies for Treatment Resistant Depression

A panel of experts explore the patient journey and unmet needs of patients with treatment-resistant depression, outline treatment strategies, and explore strategies to support access to alternative therapies.

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screenshot of panel for the Improving Access to Alternative Therapies for Treatment Resistant Depression discussion

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