Major Depressive Disorder

Latest News

July 31st 2025

Reassessing Antidepressant Efficacy: A Meta-Analysis of Control Group Outcomes in SSRI, Psilocybin, and Esketamine Trials

By Alana Hippensteele, MA

February 13th 2025

Adults With Depression Likely Develop Physical Conditions 30% Faster

By Giuliana Grossi

July 10th 2024

Significant Clinician-Level Differences Exist in Antidepressant Prescribing Patterns, Outcomes

By Giuliana Grossi

December 24th 2022

Top 5 Most-Read MDD Articles of 2022

By Justina Petrullo

December 19th 2022

Having Lower Personal Reserve Predicts Sustained Remission of Major Depression

By Justina Petrullo

Improving Access to Alternative Therapies for Treatment Resistant Depression

A panel of experts explore the patient journey and unmet needs of patients with treatment-resistant depression, outline treatment strategies, and explore strategies to support access to alternative therapies.

screenshot of panel for the Improving Access to Alternative Therapies for Treatment Resistant Depression discussion

Video Interviews

January 10th 2023

Key Contributors to Long-term Outcomes for Patients With MDD

January 10th 2023

The Impact of Early Effective Treatment in MDD

January 3rd 2023

Aligning MDD Treatment Goals for Payers and Patients

January 3rd 2023

Supporting Adherence for Patients with MDD

December 19th 2022

Factors Affecting MDD Treatment Adherence

December 19th 2022

Population Health Approach in MDD

December 12th 2022

Social Determinants of Health in MDD: Part 2

December 12th 2022

MDD Treatment Disparities Across Patient Populations: Part 2

Podcasts

May 13th 2025

Inside the Center's MDD Value Model and Its Use of Dynamic Pricing

More News

sadness

December 18th 2022

Analysis Finds Efficacy in Combining Esketamine With Antidepressants

While the combination improved multiple depression scores, patients receiving both therapies did have more adverse events than those in control groups, the meta-analysis found.

image of MDD

December 16th 2022

Mental Health Hospitalizations Among Adolescents in the US, France Rose During the Pandemic

Data from the study lend support for the need for improved global health policies related to adolescent mental health, a new study finds.

December 13th 2022

Reducing “Avoidable” ED Visits for Mental Health Could Cut Billions in Costs, Improve Patient Outcomes

Lindsey Mulrooney

The changing landscape of health care during COVID-19 placed focus on increasing accessibility to mental health resources other than the emergency department (ED), with potential savings of over $4 billion in annual costs and improvements in patient outcomes.

patient with depression or dementia

November 29th 2022

Treating Depression to Prevent Dementia

According to new research, treating depression in older adults could decrease risk of dementia by 51%.

Image of a person with depression

November 28th 2022

MDD Treatment Alternatives Explore Potential of Cannabis, Psychedelics

Jaime Rosenberg

Stemming from recent data on a potential link between major depressive disorder (MDD) and inflammation, research is starting to turn toward alternatives that can treat the disease through anti-inflammatory effects, including ketamine, cannabinoids, and psychedelics.

elderly woman

November 25th 2022

Study Details Pandemic’s Depressive Effects in Older Adults

It is well-known that depression generally, as well as the demand for mental health care, surged because of the pandemic, but few studies have identified the percentage of individuals who experienced depression for the first time after the pandemic began, or the percentage of those with a history of depression who saw it return.

Cigarette Smoking, Insurance Coverage Appear Linked in Those With Mental Health, Substance Use Disorders

November 17th 2022

Cigarette Smoking, Insurance Coverage Appear Linked in Those With Mental Health, Substance Use Disorders

Policy reforms that expand insurance coverage may play a supporting role in discouraging smoking among adults living with mental health and/or substance use disorders.

anxiety

November 11th 2022

Older Individuals With Hyperopia More Likely to Develop Incident Depression

Genetic factors previously known to predispose people to hyperopia were not risk factors for clinically significant depression in the study.

Brain

October 25th 2022

Treatment Outcomes of Ketamine-Assisted Psychotherapy Associated With Temporary Neural Changes

Julia Bonavitacola

A systematic review found that changes in neural mechanisms as a result of ketamine treatment could play a role in treatment outcomes of ketamine-assisted psychotherapy.

image depicting depression

October 25th 2022

Estimating Treatment-Resistant Depression in Taiwan Using Insurance Data

Allison Inserro

The study found that in most cases, progression to treatment-resistant depression occurred within the first year.

Brain

October 22nd 2022

Transcranial Magnetic Stimulation Appears Effective in Patients With Adverse Childhood Experiences

Repetitive transcranial magnetic stimulation offers an alternative solution that may be effective for treating depression in patients with adverse childhood experiences.

major depressive disorder image

October 20th 2022

Study Finds Links Between Alcohol Consumption and Smoking in Adolescence and Later Mood Disorders

While links between adolescent coffee habits in adolescents and mood disorders in adulthood were not seen, researchers did find evidence for later health issues related to smoking and alcohol.

graphic of brain

October 7th 2022

Study Explores Effects of Experimenter Sex on Ketamine Response

The underlying neural mechanisms identified may help clinicians better understand ketamine response in human patients.

Image of depressed person

September 22nd 2022

Childhood Trauma Not a Barrier to Successful Depression Treatment, Analysis Finds

Allison Inserro

Prior research has suggested that childhood trauma is linked with a poorer response to psychotherapy and prescription drug treatment for major depressive disorder, but a large meta-analysis suggested otherwise.

What We're Reading

September 21st 2022

What We’re Reading: Public Health Emergency in Puerto Rico; Depression Rates and Anxiety Screening; Cancer Death Rates Decrease

HHS declared a public health emergency in Puerto Rico due to Hurricane Fiona; nearly 1 in 10 Americans suffered from depression in 2020, and a task force recommended doctors screen all adults aged younger than 65 for anxiety; advances in cancer research have led to reduced cancer death rates.

Graphic of brain

September 19th 2022

Which Depression Therapies Made the Updated US Guideline for Treating MDD?

Allison Inserro

Newer therapies, such as ketamine or esketamine, or the broader use of bright light therapy, made an updated clinical practice guideline for treating major depressive disorder (MDD), but psilocybin and cannabis did not.

Closeup of Black doctor holding patient's hand

September 18th 2022

Recommendations to Increase Equitable Psychosocial Outcomes for Children and Adolescents

Allison Inserro

Nearly 30% of youths are affected with worsening mental health by the end of adolescence, with anxiety typically presenting in childhood and depression during the teenage years, but the problem is even more acute for Black and Latinx youth.

Image of diverse community members

September 15th 2022

More Diversity, Multifaceted Outreach Needed in Studies of Genetic Screening for Depression

Three types of salient beliefs were investigated in this study that examined why mothers would or would not participate in depression screening via genetic salivary testing, with the results indicating potential for mental health disparities among diverse populations.

Picture of depressed woman

September 8th 2022

Experiencing Psychological Distress Before Infection Linked With Long COVID

Allison Inserro

Feeling depressed, anxious, worried, stressed, or lonely was linked with a higher risk of developing long COVID and hurting the ability to function in daily life, according to a study published this week.

doctor talking to patient

September 2nd 2022

Routine Depression Screening in Primary Care Reduces Disparities in Screening

Laura Joszt, MA

Groups at risk for underrecognition and undertreatment of depression had improved rates of depression screening after implementing routine adult depressions screening in primary care.

an old man

April 20th 2022

Older Patients With Depression at Risk of Polypharmacy

A study conducted in the Netherlands found older adults with depression were at greater risk of polypharmacy than those without depression.

Image of patient receiving advice

January 25th 2022

Depression Screening Shown to Benefit Persons Living With Breast Cancer

This new study of data from Kaiser Permanente Southern California compared outcomes for behavioral health referrals among patients with breast cancer between those receiving a tailored intervention or an education-only approach.

graphic of 2-sided face in shadows

June 19th 2021

Analysis Supports Link Between AD, MDD Pathogenesis

Jared Kaltwasser

The analysis identified 4 genes that were driven by atopic dermatitis (AD) and which had significant expression changes in favor of MDD development.

Double helix in a container

March 12th 2021

Genetic Predisposition for Elevated BMI May Increase Risk of MS, Depression

A causal relationship between major depressive disorder (MDD) and multiple sclerosis (MS), and vice versa, was not found in a recent Mendelian randomization study, while higher body mass index (BMI) was shown to increase the risk for both.

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