Oncology

In vitro studies demonstrated a reduced incidence of apoptosis in patients administered inhaled anesthetics compared with those administered propofol during surgery.

High expression of PD-L1 was associated with the presence of EGFR mutations in surgically resected NSCLC and was an independent negative prognostic factor for this disease.

One insurer's experimental reimbursement model proved to lower the total costs of care for patients with 3 types of cancer. As an alternative to the traditional fee-for-service payment model, the episode payment model-which reimburses physicians on a fixed-price, based on episodes of best-practices and patient outcomes-provided encouraging findings in the battle against the rising costs of cancer care in the United States.

Collaborative research conducted by scientists within the Cancer Genome Atlas Research Network have identified significant mutations that can influence tumor subtype classification.

Following approval in Japan, Nivolumab will be evaluated by the FDA for melanoma therapy in the US.

There has been a sharp increase in the number of cancer patients at one hospital using MyChart, the online, interactive service that allows patients to view laboratory and radiology results, communicate with their healthcare providers, and more.

UnitedHealthcare published these findings in the latest issue of Journal of Oncology Practice.

The study by researchers at MD Anderson Cancer Center raises the possibility of using the information provided by these dysfunctional genes.

Several cancer centers have programs in place to improve communication between PCPs and oncologists.

A lipid metabolite, associated with more than 70 percent of brain cancers, can help distinguish and excise cancerous tissue.

Nivolumab, the first PD-1 inhibitor, was approved in Japan for treating unresectable melanoma. It has been developed in Japan by Ono Pharmaceutical, which also has rights in Korea and Taiwan.

GSK has received marketing authorization from the European Commission for trametinib as monotherapy for unresectable or metastatic melanoma in adults with a BRAF V600 mutation.

This week, a coalition of 32 major pharmacies, health insurers, unions and pension plans asked the FDA not to require distinct names for biosimilar medications, arguing that such a move would not compromise patient safety, but could undermine the savings that are expected to be generated as these medicines are introduced into the US health care system.

Autophagy inhibition may improve cancer therapy, but it is unclear which tumors will benefit. BRAF mutations cause brain tumor cells to depend on autophagy and display selective chemosensitization with autophagy inhibition. We present a pediatric case in which deliberate autophagy inhibition halted tumor growth and overcame acquired BRAF-inhibition resistance.

Clinical care pathways in oncology have gained notice with WellPoint's announcement of a $350 per patient, per month incentive. As WellPoint's effort starts this week, The American Journal of Managed Care convened a panel with the insurer's medical director for oncology care, ASCO President Peter Paul Yu, MD, and two other voices from the payer and provider realms to discuss how pathways are changing cancer care.

The lack of OS advantage is the reason for the discontinuation.

Despite increased spending, the breast cancer detection rate and stage did not change, according to a new JNCI study.

It could be the first anti-PD-1 therapy in Europe, if approved.

Breakthrough Designation Reinforces Significant Unmet Need in the Treatment of This Highly Aggressive Cancer

For patients with KRAS wild-type untreated colorectal cancer, adding cetuximab or bevacizumab to combination chemotherapy offers equivalent survival, researchers said at the ESMO 16th World Congress on Gastrointestinal Cancer in Barcelona

The panelists further explore feedback and its role in pathway adherence.

Dr Yu said that it is crucial for providers' voices to be heard in pathway development.

Patients with non-Hodgkin's lymphoma who have received 8 or more CT scans have a 2-fold risk for secondary primary malignancies, new research shows.