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Circadian disruptions were associated with an increased risk of Parkinson disease (PD) in older men, potentially signifying PD’s impact on the internal clock before diagnosis.

The FDA today granted accelerated approval to the second biomarker-based indication for Merck’s pembrolizumab (Keytruda), an anti-PD-1 therapy, regardless of tumor type. A companion diagnostic to pembrolizumab, FoundationOne CDx was also today approved by the FDA as only approved companion diagnostic to measure tumor mutational burden.

US children with developmental disabilites were found to be at a greater risk for asthma; nursing homes attributed to 43% of US deaths due to coronavirus disease 2019 (COVID-19); cloth masks recommended when wearing a mask during exercise.

Measuring disease activity is a key aspect of rheumatologic care, but the creation of tools designed specifically for disease areas of interest has resulted in fragmentation and multiple disease activity scores, sometimes even just for a single disease.

US children with developmental disabilities were found to be at a greater risk for asthma; nursing homes attributed to 43% of US deaths due to coronavirus disease 2019 (COVID-19); cloth masks recommended when wearing a mask during exercise.

A study conducted by Mayo Clinic researchers revealed that a combined treatment featuring daratumumab in conjunction with the standard-of-care for patients with amyloid light-chain (AL) amyloidosis was more effective in improving the condition than the standard treatment alone.

Cases of triple-negative breast cancer (TNBC) account for up to 20% of all cases of the disease, the most common cancer diagnosed in women in the United States.

A study conducted in Boston-area hospitals found low prevalence of asymptomatic coronavirus disease 2019 (COVID-19) infections among pregnant women, while a systematic review concluded maternal transmission of the virus to neonates is uncommon.

Officials associated with Operation Warp Speed, the administration's initiative to speed development for a vaccine for coronavirus disease 2019 (COVID-19), claimed that doses for elderly patients and other vulnerable populations would be made available free of charge if they cannot afford it.

Investigators reported in Lancet Oncology that second-line treatments are needed in small cell lung cancer, as few options exist for these patients once first-line therapy fails.

Study results out of Denmark show that 0.08% of patients with heart failure received a diagnosis of coronavirus disease 2019 (COVID-19) in the time after a country-wide lockdown began on March 12.

Researchers uncovered that an ambulatory home sleep study device may lead to earlier diagnosis and treatment of obstructive sleep apnea, according to the study findings.

Despite initiating antiretroviral therapy, overall and comorbidity-free–associated survival remain below that of the population without HIV.

Spending on public health in the United States continues to drop; HHS rules to remove protections on transgender people and women seeking abortions; can additional pandemic-related shutdowns be avoided?

Studies with better data are still needed to fully understand the epidemiology of Duchenne muscular dystrophy (DMD), according to a recently published review.

Patients with sickle cell disease who do not receive treatment can die from the disease, but diagnostic resources are scarce in some parts of the world where the disease is most prevalent. A new smartphone-based method could change that.

Today, there is a broader understanding of asthma, including the genetic, environmental, and host-related factors that contribute to declining lung function in patients.

Research at the European Hematology Association featured zanubrutinib as monotherapy and in combination with rituximab, and well as evaluations of biomarkers that signal responses.

Researchers warned that financial incentives that focus on a percentage of pathway compliance could “paradoxically harm the quality of care."

Patients with relapsed/refractory T-cell lymphoblastic leukemia face poor outcomes, and are generally treated by salvage therapy followed by allogeneic hematopoietic stem cell transplant. A new study suggests an optimal option for salvage therapy.

Experiments with the protein Cx43 show that it could be a "druggable target" to prevent renal decline.

Authors of an opinion piece concluded that not only are immunosuppressed patients with psoriasis not at an increased risk of developing serious complications related to coronavirus disease 2019 (COVID-19), their medications may help mitigate potential issues.

A subset of patients taking ibrutinib as a therapy for chronic lymphocytic leukemia (CLL) will require dose modifications. A new study attempts to evaluate the impacts of such changes, though the authors find many questions remain unsolved.

The challenges in precision oncology in gastric cancer is driven by its inter- and intra-tumoral heterogeneity, leaving chemotherapy as the standard of care.

Two abstracts presented at the European Congress of Rheumatology of the European League Against Rheumatism reviewed long-term safety data and real-life effectiveness and safety of secukinumab for ankylosing spondylitis, psoriasis, and psoriatic arthritis.

The advice comes a week before Donald Trump seeks to hold an indoor re-election rally for his presidential campaign in Tulsa, Oklahoma.

Alcohol consumption was found to contribute to the lowest oxygen saturation observed among patients at risk of snoring and obstructive sleep apnea, with additional associations linked to worsening severity of snoring and impaired sleep architecture in select groups, according to study findings.

Study results show a 4% mortality rate among HIV-positive patients who have coronavirus disease 2019 (COVID-19) compared with approximately 17% of patients who also have COVID-19 but are HIV-negative.