COPD

In-home noninvasive positive pressure ventilation via bilevel positive airway pressure devices exhibited lower risk of mortality, fewer patients with all-cause hospital admission, and less need for intubation, but had no significant difference in quality-of-life for patients with chronic obstructive pulmonary disease (COPD) and hypercapnia, according to study findings.

The researchers hope the findings could one day lead to cell replacement therapies for respiratory diseases, including chronic obstructive pulmonary disease.

Among patients with chronic obstructive pulmonary disease (COPD), heart failure, stroke, and myocardial infarction were highly associated with an increased risk of death. Mortality risk was more strongly associated with the use of long-acting muscarinic antagonists and N-acetylcysteine compared with the lesser risk from inhaled corticosteroids, beta-blockers, and acetylsalicylic acid, according to study findings.

Although arterial stiffness in patients with chronic obstructive pulmonary disease (COPD) increases over time, a greater annual increase may be associated with the severity of emphysema, systemic inflammation, and dyslipidemia, according to study findings.

In study findings demonstrating differentially expressed genes (DEGs) among healthy patients and those with chronic obstructive pulmonary disease (COPD), researchers show that key genes CYP1B1, VEGFA, BCL2, and CDKN1A may have significance in analyzing the development and progression of COPD.

Extracting lung function measurements from electronic health record (EHR) data through an automated tool, such as Microsoft SQL Server’s full-text search feature, may be efficient and improve the number of values available, leading to improved phenotyping of patients with COPD, according to study findings.

Researchers discuss optimal approaches to treating hypertension in patients with COPD, with a given patient’s underlying lung function and any coexisting conditions highlighted as important factors of drug therapy choice.

Tracheobronchial colonization by pseudomonas aeruginosa was shown to increase the mortality risk of outpatients with chronic obstructive plumonary disease (COPD) by 47%, according to study results.