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Opinion|Videos|May 23, 2025

CROI 2025 Insights: Evolving HIV Treatment Landscape and Practice-Changing Developments

A panelist discusses how HIV treatment has evolved with tremendous improvements in efficacy, tolerability, and convenience, with exciting developments at the Conference on Retroviruses and Opportunistic Infections 2025, including new long-acting therapies for treatment and prevention that could last up to 2 years.

Episodes in this series

Future Directions in HIV Treatment

Key Themes:

  • Treatment Evolution: Continuous improvement in HIV medications regarding efficacy, tolerability, and convenience
  • Long-Acting Formulations: Development of oral, subcutaneous, intramuscular, and intravenous options
  • Combination Products: Future devices potentially combining HIV treatment/prevention with contraception or sexually transmitted infection prevention
  • HIV Prevention: New preventive therapies potentially effective for 1 to 2 years

Notable Insights from Dr Sharon Walmsley:

  • Long-acting therapies help “demedicalize” HIV by reducing medication frequency.
  • New challenges in adherence emerge with transition from daily to weekly or monthly dosing schedules.
  • HIV treatment advances have informed approaches to other infectious diseases, including COVID-19 and Mpox.
  • Despite prevention advances, questions remain about whether to continue vaccine development efforts given limited success to date.

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