Video

Dr Thomas Frisell Addresses Cardiac Safety of Ozanimod Versus Fingolimod in MS

Patients with multiple sclerosis (MS) have a generally increased risk of cardiovascular disease, and some evidence is emerging that disease-modifying treatments may alter this risk. Thomas Frisell, PhD, coordinator of the Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden, discusses whether newer treatments for MS, such as ozanimod, may present an improved cardiac safety profile for patients with MS versus older treatments, such as fingolimod.

Patients with multiple sclerosis (MS) have a generally increased risk of cardiovascular disease, and some evidence is emerging that disease-modifying treatments may alter this risk. Thomas Frisell, PhD, coordinator of the Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden, discusses whether newer treatments for MS, such as ozanimod, may present an improved cardiac safety profile for patients with MS versus older treatments, such as fingolimod.

Transcript

Do newer drugs like ozanimod present an improved cardiac safety profile for patients with MS?

So that has been argued, because that’s a drug that works like fingolimod, but is more specific, or selective, so it should have less of that transient heartrate effect. And that sounds good, right?

Well, in our data, we didn’t see an increased risk of cardiovascular disease in fingolimod either, so I’m not sure. Our data wasn’t perhaps big enough, and we didn’t have enough follow-up to really rule out increased risk on fingolimod. So it’s too early to say whether the new therapies will actually be beneficial compared to fingolimod, I would say.

Related Videos
Dr Cesar Davila-Chapa
Screenshot of an interview with Nadine Barrett, PhD
Milind Desai, MD
Masanori Aikawa, MD
Neil Goldfarb, GPBCH
Mabel Mardones, MD.
Mei Wei, MD, an oncologist specializing in breast cancer at Huntsman Cancer Institute at the University of Utah.
Alexander Mathioudakis, MD, PhD, clinical lecturer in respiratory medicine at The University of Manchester
Screenshot of Susan Wescott, RPh, MBA
Screenshot of an interview with Adam Colborn, JD
Related Content
AJMC Managed Markets Network Logo
CH LogoCenter for Biosimilars Logo