Cameron Santoro

The review explores the potential link between alopecia areata (AA) and cysteine metabolism. Research suggests insufficient cysteine levels or disruptions in its processing could contribute to AA development. Further studies are needed to confirm these connections and explore potential therapeutic strategies targeting cysteine metabolism for AA treatment.

A Swedish study suggests bariatric surgery may lower breast cancer risk in obese women, particularly those with high insulin levels at baseline.

This scientific review examines the potential of targeting the thyroid receptor β (TRβ) for developing new drugs to treat androgenetic alopecia, with the authors discussing various mechanisms by which TRβ might work and analyze promising drug candidates.

The ENV-101 phase 2a trial for idiopathic pulmonary fibrosis (IPF) focused on assessing safety, lung function, and fibrosis, with plans for further trials, combination therapies, and strategies to manage adverse effects.

This study highlights the lack of clear guidelines for breast cancer management in transgender men after chest contouring surgery. While data is limited, the authors suggest adapting existing recommendations for cisgender women and implementing risk management strategies like pre-surgery evaluation and education.

In a European expert consensus statement, researchers discover the exciting breakthroughs for patients with alopecia areata (AA). This article explores the unlocked potential of combination therapies and targeted biologics to regrow hair and transform lives.

A recent study found that neighborhood deprivation is associated with higher breast cancer death rates for non-Hispanic White women, but not Black women. This suggests factors beyond socioeconomic status contribute to the racial disparity.

John Hood, PhD, cofounder and CEO of Endeavor BioMedicines, explains the potential advantages of ENV-101 during a time with very few treatments for idiopathic pulmonary fibrosis (IPF).

Different Janus kinase (JAK) inhibitors underwent an evaluation for severe alopecia areata (AA) and found deuruxolitinib higher doses (12 mg) and baricitinib (4 mg) showed promise in hair regrowth improvement, but further research must be done to confirm these results while more long-term effects are explored.

In a recent update, the National Comprehensive Cancer Network (NCCN) recommended capivasertib combined with fulvestrant for hormone receptor–positive and HER2-negative locally advanced or metastatic breast cancer, targeting patients with specific genetic mutations.

Findings from ASCO 2024 suggest deruxtecan (T-DXd) may become a preferred first-line treatment for patients with hormone receptor (HR)-positive, HER2-low metastatic breast cancer that progressed after endocrine therapy.

Scalp-cooling therapy (SCT) is a treatment that may help reduce hair loss in women with breast cancer who are experiencing chemotherapy-induced alopecia (CIA). A study found that many women who used SCT were satisfied with the results, but the treatment is expensive, making it necessary for more advocacy by health care professionals to make SCT accessible.

Surya Bhatt, MD, MSPH, of the University of Alabama at Birmingham, explained the phase 3 BOREAS and NOTUS trials demonstrated comparable safety profiles for dupilumab in treating patients with chronic obstructive pulmonary disease (COPD).

Patients with breast cancer who participate in a tailored exercise program after surgery have better shoulder function after 1 month compared with those who received usual care.

Surya Bhatt, MD, MSPH, of the University of Alabama at Birmingham, discussed the challenges of diagnosing chronic obstructive pulmonary disease (COPD) with type 2 inflammation, as well as the promising efficacy of dupilumab in treating this condition.

A large US study showed population-based multigene testing might be a cost-effective way to identify women at risk for breast and ovarian cancer, potentially preventing more cases but raising concerns about generalizability and cost.

The FDA approved mRNA-1345, a Moderna vaccine for the treatment of respiratory syncytial virus (RSV). This single-dose vaccine offers protection against lower respiratory tract disease in adults over 60 years, with data suggesting long-term effectiveness.

A case controlled study suggests a gene variant may offer some protection from frontal fibrosing alopecia (FFA), but only if there is no prior history of oral contraceptive pill use, which appears to increase the risk for carriers of this variant.

Platelet-rich plasma (PRP) treatment increased hair regrowth in patients with androgenetic alopecia (AGA) and may help rebalance the scalp microbiome, although the link between the microbiome changes and hair growth needs future investigations.

Leda Mannent, MD, global project head, Immunology and Inflammation, Sanofi, shares findings on the use of a novel treatment for patients with moderate to severe asthma.

A US study found that a commercially available artificial intelligence (AI) algorithm for breast cancer screening produced more false-positives in Black patients and people with denser breasts, highlighting the importance of diverse datasets in training AI algorithms to reduce health care disparities.

A study using a large Korean health database found that people with a rare hair loss disorder called primary cicatricial alopecia were more likely to also have additional health problems like diabetes and high blood pressure compared with people who had other hair loss conditions or no hair loss at all.

Expert speakers at the American Thoracic Society (ATS) 2024 international conference share their favorite parts of the event and the key takeaways they will leave the conference with.

Monica Kraft, MD, ATSF, contributed to research on preexisting asthma and the influence it may have on the severity of long-term COVID-19 symptoms, with some patients with asthma experiencing worse respiratory symptoms but better physical functioning compared with patients without asthma.

Michael Arzt, MD, investigated the use of ASV therapy in patients with TE-CSA and cardiovascular disease, finding it effective in reducing sleepiness and improving quality of life. It may be more suitable for some patients to be treated with ASV than CPAP due to its ability to automatically adjust pressure and potentially improve comfort.

Julie Linton, MD, FAAP, immediate past chair of the American Academy of Pediatrics (AAP) Council on Immigrant Child and Family Health, discussed disparities within health care services impacting immigrant populations in the United States.

Jan Hedner, MD, PhD, finds sulthiame improves sleep quality and reduces daytime sleepiness in patients with sleep-disordered breathing (SDB), offering a potential alternative to continuous positive airway pressure (CPAP) machines. This highlights the growing field of non-CPAP treatments, with personalized medicine being a key focus for future research.

In research presented at the American Thoracic Society 2024 International Conference, Benjafield and colleagues explored the treatment of sleep-disordered breathing with adaptive sero-ventilation (ASV) in opioid users with central sleep apnea (CSA).

Promising results from a phase 2 trial of ENV-101, a novel hedgehog inhibitor, showed improvement in lung function and reduction of fibrosis in patients with idiopathic pulmonary fibrosis, said Paul Frohna, MD, PhD, PharmD.