Hayden E. Klein

Ron Do, PhD, associate professor of the Charles Bronfman Institute for Personalized Medicine at the Icahn School of Medicine at Mount Sinai, and Iain Forrest, MD-PhD candidate in Dr Do’s lab, explain the importance of their recent study measuring population-based penetrance of pathogenic and loss-of-function clinical variants.

Dennis P. Scanlon, PhD, professor of health policy and administration at Pennsylvania State University and editor-in-chief of The American Journal of Accountable Care, discusses his 2021 end-of-year letter calling on health system leaders to learn and innovate in real time.

The CDC Morbidity and Mortality Weekly Report also covered varying COVID-19 vaccination coverage among people living with HIV (PLWH) in New York.

According to the authors, this is the first study to approach methotrexate intolerance measurement from a patient perspective.

William Schaffner, MD, medical director at the National Foundation for Infectious Diseases (NFID), and Patsy Stinchfield, RN, MS, CPNP, president-elect of NFID, explain how the COVID-19 pandemic has had an impact on the seasonality of respiratory syncytial virus (RSV).

Kenneth Cohen, MD, FACP, executive director of clinical research at UnitedHealth Group Research and Development and senior national medical director at OptumCare, discusses areas where low-value care is more prevalent and the shift to high-value care.

Geoffrey Boyce, CEO of Array Behavioral Care, explains how behavioral health care differs between in-person and telehealth care.

Research suggests a shorter 5-day antibiotic regimen for childhood community-acquired pneumonia, instead of 10 days, can optimize treatment efficacy while reducing unnecessary antibiotic use.

The changes come as Tennessee Oncology must now plan for a gap between the Oncology Care Model and a future alternative payment model from CMS.

Natalie Dickson, MD, president and chief strategy officer of Tennessee Oncology, discusses challenges for Tennessee Oncology and community oncology in general.

New data from the CDC’s latest Morbidity and Mortality Weekly Report highlight disparities of HIV diagnoses among Black adults in the United States.

Ted Mikuls, MD, MSPH, Stokes-Shackleford professor of rheumatology, vice chair for research, internal medicine at the University of Nebraska, explains how lower extremity amputation among US veterans with gout was independent of body mass index (BMI) and other risk factors.

Kenneth Cohen, MD, FACP, executive director of clinical research at UnitedHealth Group Research and Development and senior national medical director at OptumCare, discusses evidence-based education and other tools to address low-value care.

Version 5 of “COVID-19 Vaccine Clinical Guidance Summary for Patients with Rheumatic and Musculoskeletal Diseases" includes updated recommendations that differentiate supplemental and booster doses for people with rheumatic and musculoskeletal diseases (RMDs).

Steven Pergam, MD, MPH, director of infection prevention at Seattle Cancer Care Alliance and infectious disease physician at Fred Hutchinson Cancer Research Center, discusses delayed booster vaccines and potential fourth doses for people who are immunosuppressed.

Sunil Verma, MD, senior vice president and global head of oncology, medical at AstraZeneca, explains the background and results of the TOPAZ-1 study.

Sunil Verma, MD, senior vice president and global head of oncology, medical at AstraZeneca, summarizes the benefits and safety findings discovered in the HIMALAYA study.

Research showed that younger and nonfrail patients with COVID-19 were more likely to be put on a ventilator, while patients with frailty and older age had a higher risk of in-hospital and in-ICU mortality.

Patients with rheumatoid arthritis (RA) who used 3 or more targeted therapies, but not Janus kinase inhibitors, were at greater risk of developing herpes zoster, according to findings from a Korean study.

Ted Mikuls, MD, MSPH, Stokes-Shackleford professor of rheumatology, vice chair for research, internal medicine at the University of Nebraska, discusses his study comparing rates of lower extremity amputations in US veterans with and without gout, using data from the national Veterans Health Administration.

Researchers have discovered a highly virulent HIV-1 variant in the Netherlands that causes immune system strength to decline twice as fast vs other HIV strains.

Geoffrey Boyce, CEO of Array Behavioral Care, discusses Array AtHome’s telebehavioral health services, which are now available to approximately 5 million Humana Medicare Advantage members.

COVID-19 vaccine uptake among people living with HIV was associated with older age, more years living with HIV, higher education level, and higher perceived COVID-19 vulnerability.

Sunil Verma, MD, senior vice president and global head of oncology, medical at AstraZeneca, explains the design of the HIMALAYA study, including the dosing strategy used.

A study found that antibody response against COVID-19 decreased by 2.8 times between months 1 and 6 post vaccination among people with rheumatic and musculoskeletal disease.

The review discussed the roles of sex, ancestry, senescence, and aging in the development of nontuberculous mycobacterial pulmonary disease.

Speakers at the Greater Philadelphia Business Coalition on Health (GPBCH) discussed data on lifestyles, economic trends, and presented real-life examples of obesity treatment, as well as a benefit design for obesity.

After analyzing past studies and classification criteria, authors found multiple factors that could be implemented into the current rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) tests for a more specific rheumatoid arthritis (RA) classification.

Women in the study were 3 times more likely to be affected by rheumatoid arthritis (RA) and nearly 4 times more likely to develop hypothyroidism, compared with men.

Implementing evidence-based guidelines (EBGs) resulted in a 17.3% reduction in anaphylaxis-related hospitalizations among children.