Bone Health

Acute lymphoblastic leukemia is the most common type of childhood cancer, and fractures from osteoporosis are an important cause of morbidity in patients with ALL. A recent study aimed to document the annual incidence and predictors of fractures in order to determine whether they occur years after chemotherapy.

Can older women with low bone mass decrease their risk of falls with a fitness trend called explosive jumping? One study says it’s possible, and that it may be worthwhile to incorporate muscle power training into traditional fall-prevention programs.

A recent study found an association between heavy drinking by adolescent females and poorer bone mass later on.

The United States Preventive Services Task Force (USPSTF) updated its 2011 recommendation about osteoporosis screening, recommending that women over the age of 65 years continue to get screened and issuing new information about how clinicians should use screening tools to evaluate women younger than 65 years at high risk for developing the bone disease.

A recent study aimed to determine the clinical and laboratory parameters associated with increased fracture risk in patients on holidays from taking bisphosphonates (BP) for osteoporosis.

Biotechnology firm Pfenex recently reported results from its phase 3 PF708-301 study, which showed comparable overall profiles between its biosimiliar drug candidate PF708 and Eli Lilly’s teriparatide (Forteo) for osteoporosis.

A study comparing denosumab (Prolia) with risedronate (Actone) found that denosumab could be a useful treatment option for patients newly initiating or continuing glucocorticoids who are at risk of fractures. It is the first study to show that denosumab can increase bone mineral density at both the spine and the hip in patients with glucocorticoid-induced osteoporosis.

National Institutes of Health researchers have uncovered a genetic basis of a rare bone disease known as melorheostosis and said the discovery could offer potential treatment targets, provide clues about bone development, and lead to insights about fracture healing and osteoporosis.

The authors observed a marked shift toward treatment of higher-risk subsets of younger postmenopausal women (with prior fracture and/or with osteoporosis), and away from women at lower risk.

Authors of the study say the technology exists to screen seniors with type 2 diabetes and identify those at risk of a fracture.

Racial and ethnic differences in hip fracture incidence and mortality outcome were observed within a diverse population of older men, with lower rates of both among Asians.

Researchers say more work is needed to create calculators that predict fracture risk in individual patients with diabetes.

One-year mortality following hip fracture in Asian American women is comparable among Chinese, Japanese, and Filipina women, comprising nearly three-fourths of the Asian population examined.

The authors used the modified Delphi method to develop local orthopedic referral guidelines, enabling detailed decision support and non—face-to-face consultation at the point of referral.

The standard test for osteoporosis does not do a good job of predicting fractures in T1D.

NCCN Guidelines Updates