Comprehensive Genomic Profiling

More Patients With Advanced Tumors May Benefit From Genomic Profiling Testing Than Previously Thought

September 21st 2021, 9:00pm


Polymerase chain reaction–based comprehensive genomic profiling testing provided useful information for more than 94% of samples, including 81% of samples that normally would not have been tested, suggesting that more patients may benefit from CGP testing than anticipated.

Study Detects Biomarkers for Poor Prognosis in Premenopausal Patients With HR+/HER2– Advanced Breast Cancer

September 18th 2021, 4:20pm


Investigators confirmed prognostic biomarkers for premenopausal patients with hormone receptor–positive (HR+) and human epidermal growth factor receptor 2–negative (HER2–) advanced breast cancer, which could potentially be used to inform treatment decisions.

The Role of Liquid Biopsy in Determining Prognosis, Treatment in Surgical Oncology

September 15th 2021, 9:20pm


A literature review detailed the multitude of ways that liquid biopsy can be used to aid the treatment of patients with cancer, including aiding in screening, recurrence surveillance, genomic profiling, and therapeutic decision-making.

Prognostic Biomarkers Identified for Pancreatic Ductal Adenocarcinoma Using Whole Genome Sequencing

September 11th 2021, 5:00pm


Investigators identified 5 mutated genes that could serve as biomarkers for disease prognosis and clinical outcomes associated with pancreatic ductal adenocarcinoma, a common cancer with a high mortality rate and poor prognosis.

Study: Serial Liquid Biopsy May Be Useful in Identifying RAS Genetic Mutations in mCRC

September 3rd 2021, 8:01pm


Investigators identified serial liquid biopsy as an effective tool for identifying mutational changes of RAS genes in patients with metastatic colorectal cancer (mCRC) who have undergone antiangiogenic therapy.

Copy Number Signatures Predict Chromothripsis, Prognosis in Newly Diagnosed MM

September 2nd 2021, 2:00pm


Using whole genome sequencing, copy number signatures were successful in predicting both the presence of chromothripsis and clinical outcomes in patients with newly diagnosed multiple myeloma (MM).

Foundation Medicine, Epic Partner on Access to Genomic Profiling in EHRs

August 26th 2021, 8:22pm


Foundation Medicine and Epic struck a deal to integrate comprehensive genomic profiling within Epic's electronic health records (EHRs), allowing for providers to order and review genomic profiling tests, leading to more streamlined clinical decision making.

Study Finds Individuals Carry Genetic Variants for Actionable Monogenic Disorders

August 25th 2021, 7:30pm


Approximately 1 in 6 healthy individuals who underwent proactive genetic screening had genetic variants linked to increased risk for developing medically actionable disorders, including certain cancers and cardiovascular disorders.

Review Outlines Potential Benefits, Challenges of Next-Generation Sequencing for Early-Stage NSCLC

August 18th 2021, 8:15pm


Investigators examined the current bodies of evidence surrounding the emergence of next-generation gene sequencing, and the challenges that come with it, for identifying oncogenic drivers of early-stage non–small cell lung cancer (NSCLC).

Impact of Expanded Carrier Screening on Health Care Utilization

August 11th 2021, 4:00pm


This study shows little evidence of harms or increased health care utilization for people receiving negative (normal) results of expanded carrier screening through genome sequencing.