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Javed Butler, MD, MPH, MBA, discusses the 2018 American College of Cardiology Expert Consensus Decision Pathway, which includes guidance on the use of SGLT2 inhibitors and GLP-1 receptor agonists, and its potential to change the treatment paradigm for patients with type 2 diabetes.

Sephin1 provided protective benefits that delayed loss of myelin and onset of debilitating disease in mouse models of multiple sclerosis.

A recent review showed that the long-term use of statins reduced the risk of acute exacerbation in chronic obstructive pulmonary disease (COPD), heart disease–related mortality and all-cause mortality, as well as decreased inflammatory factors.

The FDA has approved sumatriptan nasal spray (Tosymra) for the acute treatment of migraine with or without aura in adults.

Being able to accurately measure HIV reservoirs that remain in the body even during viral suppression is the first step to being able to destroy these reservoirs and, potentially, cure the infection. Researchers say they've created a new technique that will allow them to do so.

Prior to the Affordable Care Act, many adults leaving jail or prison were ineligible for Medicaid because coverage was not available to most adults without children. However, by mid 2018, 33 states and the District of Columbia had expanded Medicaid eligibility to include all adults with incomes below 138% of the federal poverty level, which has made Medicaid available to more individuals upon their release.

As many as 2 million people have been exposed to carcinogens in several generic blood pressure drugs; flu activity has worsened over the past week; and real-world data is changing how researchers study drug efficacy and safety.

The study followed more than 2300 men and women for 5 years and found different patterns of depression symptoms between the genders.

Here are 5 interesting findings from the January 2019 issue of AJMC®.

Americans with primary care receive significantly more high-value care, slightly more low-value care, and report better healthcare experience.

https://www.pharmacytimes.org/on-demand/an-american-journal-of-managed-care-medical-crossfire-a-payer-and-neurologist-discussion-on-the-shifting-paradigm-of-alzheimers-disease-treatment

https://www.pharmacytimes.org/on-demand/an-american-journal-of-managed-care-payer-and-specialty-pharmacy-forum-clinical-updates-and-outcomes-data-for-pcsk9-inhibitors

https://www.pharmacytimes.org/on-demand/chemotherapy-induced-nausea-and-vomiting-treatment

https://www.pharmacytimes.org/on-demand/a-managed-care-perspective-on-immunotherapy-treatment-for-peanut-allergies

https://www.pharmacytimes.org/on-demand/american-journal-of-managed-care-payer-and-specialty-pharmacy-forum-von-willebrand-disease-management-including-a-patient-perspective

https://www.pharmacytimes.org/on-demand/mantle-cell-lymphoma-mcl-treatment-landscape-and-access-to-care

Asthma–COPD overlap (ACO) is a term that encompasses patients with characteristics of 2 conditions, asthma and chronic obstructive pulmonary disease (COPD). A recent study from Spain sought to validate a proposed algorithm to help clinicians identify ACO among patients with COPD, in an effort to tailor treatment.

Administrator Seema Verma said CMS will focus on “empowering patients, focusing on results, and unleashing innovation” during a speech on the first day of the 2019 CMS Quality Conference, and called states the “laboratories of democracy” when it comes to innovation in Medicaid.

The study appeared as one of its authors testified before Congress on the high cost of prescription drugs, including insulin. Experts told the House Committee on Oversight and Reform that branded drug makers enjoy monopolies and that barriers to competition harm consumers.

UPMC Health Plan and AztraZeneca have announced their value-based agreement for ticagrelor (Brilinta), which will tie reimbursement to patient outcomes.

The man for whom the right-to-try law is named has been unable to get treatment; neuroscientists who were once skeptics are now being persuaded by new studies that have turned up fascinating links between the microbiome and the brain; public health officials are worried it could take months to contain the measles outbreak due to a lower-than-normal vaccination rate in Clark County, Washington, the epicenter of the crisis.

The National Institutes of Health halted the landmark SPRINT study in 2015 after results clearly showed a cardiovascular benefit for patients who had their systolic blood pressure aggressively controlled to 120 mm/Hg.

Genomic sequencing at birth has the potential to shift the healthcare system from reactive to preventive and save countless lives in the process, but healthcare systems aren’t ready for widespread implementation of these tests, according to a panel discussion at the World Economic Forum Annual Meeting in Davos, Switzerland.

The ninth annual Trending Now in Cancer Care survey identified current and emerging trends for US cancer programs, such as the ongoing threat of drug costs and popular services progams are planning to add in the next 2 years.

The approval marks the first non-chemotherapy combination regimen for the treatment of patients with chronic lymphocytic leukemia (CLL).

Oncology medications, disease-modifying agents, and immunomodulatory agents will continue to account for most of the pharmacy spending by health systems, said Vizient, which projects a 4.28% increase for pharmaceutical purchases made by organizations between July 1, 2019, and June 30, 2020.

A recent study reports that monocytes from patients with myeloproliferative neoplasms (MPNs) have a defective negative regulation of Toll-like receptor (TLR) signaling that allows for the unrestrained production of tumor necrosis factor alpha after TLR activation. Additionally, the authors write that TLR signaling not only contributes to chronic inflammation in patients with MPN, but also may predispose individuals to acquire MPNs.

Federal contractors lost not only wages during the 5-week government shutdown, some of them also lost health insurance; with advances in gene therapy, scientists are beginning to talk about a cure in sickle cell disease; there’s bipartisan interest in attacking the issue of unexpected medical bills, and the effort has been aided by President Donald Trump, who voiced support last week for protecting patients.