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There are promising signs that chimeric antigen receptor (CAR) T-cell therapies might lead to meaningful advances in the therapy of multiple myeloma. However, investigators will first need to clear a number of key hurdles.

Most patients who have multiple sclerosis (MS) begin with a relapsing-remitting phase and eventually transition to a secondary progressive phase. In between is believed to be a “transitional” phase, but scientists have yet to discover how to clearly identify patients in transition.

Looking into a deep red light for 3 minutes each day may significantly improve declining eyesight, according to a study published in Journals of Gerontology.

Applicants should show how they would measure biosimilars use and safety in both academic and community practice settings.

Behavioral sleep problems in childhood, such as impaired sleep duration and irregular routines, were associated with the onset of either psychosis or borderline personality disorder later in adolescence, signaling potentially different pathways based on personalized sleep issues.

Despite ongoing disparities in the use of health care services among races/ethnicities and ages, as well as by insurance status, African American women with advanced breast cancer benefited the most following implementation of the Affordable Care Act in states that chose to expand Medicaid coverage.

Oklahomans vote to expand Medicaid amid the coronavirus disease 2019 (COVID-19) pandemic; Anthony Fauci, MD, cautions Congress that the daily number of new COVID-19 cases could reach 100,000 if outbreaks are not suppressed; public health departments must fight the spread of COVID-19 with lower funding and insufficient staff.

Deep brain stimulation (DBS) implanted in early-stage Parkinson disease (PD) was found to decrease the risk of disease progression. If findings are replicated in a larger trial recently approved by the FDA, DBS would be the first therapy proven to slow the progression of any element in PD.

Among patients with rheumatic diseases, medication nonadherence remains a significant problem because of a lack of standardization and guidance on terminology, measurement, and outcome selection, according to an abstract presented at the European Congress of Rheumatology of the European League Against Rheumatism.

The American Academy of Neurology (AAN) and the American Headache Society (AHS) released updated guidance on short-term treatment of migraine in children and adolescents.

The investigators conducted the study to understand more about the influence of each predictive factor of mortality in chronic obstructive pulmonary disease (COPD), as rates of death from the pulmonary disease have risen worldwide.

Federal and state officials have implemented policies and safeguards to slow transmission of the virus. Most troubling were state moratoriums on “elective” surgical procedures.

Plant-based diets have been shown to improve both ejection fraction and cardiac remodeling in patients with heart failure among a recent review of interventional studies, thereby lessening the adverse effects of obesity, hyperlipidemia, hypertension, and diabetes.

Exacerbation of air pollution and heat exposure related to climate change are significantly associated with serious adverse pregnancy outcomes in the United States, results from a systematic review published in JAMA Network Open show. In response to increasing levels of ozone and particle pollution, 17 attorneys general this week called on the Trump administration to strengthen standards regulating particulate matter pollution.

A Taiwanese study revealed that attributes associated with polycystic ovary syndrome (PCOS) may increase the risks of those patients developing psoriasis as well.

Voters in Oklahoma will decide whether or not to amend the state's constitution to expand Medicaid; new studies find that nearly 300 children in the United States have contracted a rare inflammatory disorder related to coronavirus disease 2019 (COVID-19); the House of Representatives passed a bill aimed to bolster the Affordable Care Act.

Patients with steroid refractory acute graft-versus-host-disease (GVHD) have a better overall response rate (ORR) when treated with ruxolitinib compared with the best available therapy, according to results from a phase 3 trial presented at the European Hematology Association’s annual meeting.

The decision comes almost exactly a month after results from KEYNOTE-177 were presented at the annual meeting of the American Society of Clinical Oncology.

A study analyzing patients with psoriasis revealed that personality traits may have a greater impact on the development of social anxiety than disease severity.

Metformin-based therapy may be an optimal first-line treatment for patients with type 2 diabetes (T2D) and low cardiovascular risk, according to a systematic review and network meta-analysis published in Annals of Internal Medicine.

The FDA approved Phesgo (pertuzumab/trastuzumab/hyaluronidase-zzxf) as a subcutaneous (SC) treatment for adult patients with metastatic human epidermal growth factor receptor 2 (HER2)-positive breast cancer or early-stage HER-2 positive disease. The treatment combines 2 monoclonal antibodies in a single SC injection.

Both frontline and nonfrontline health care workers were found to experience stark levels of stress and poor sleep quality amid the coronavirus disease 2019 (COVID-19) pandemic, with being female and having a professional background indicated as predictors of these effects, according to study findings.

In the United States, Gilead Sciences set the price for remdesivir, its antiviral drug that can shorten hospitalization stays for individuals ill with coronavirus disease 2019 (COVID-19), based on insurance factors, and is allowing generic drug makers to create the drug for less in low to middle income countries.

Being on an antiretroviral treatment (ART) regimen of tenofovir disoproxil fumarate/emtricitabine may lower the risk of HIV-positive individuals contracting coronavirus disease 2019 (COVID-19).

Aging and longer axial length are independent and significant risk factors for myopic maculopathy, according to a study published in JAMA Ophthalmology. The study also found the condition, which is the leading cause of irreversible visual impairment and blindness for middle-aged and older individuals, has a much higher prevalence rate in Japan compared with other Asian countries.

Female migraineurs tend to exhibit longer attack duration and greater frequency of nausea, vomiting, osmophobia, and vertigo/dizziness, compared with male migraineurs, according to a community-based study.

Lockdown because of coronavirus disease 2019 (COVID-19) is not an option in impoverished and war-torn countries; the FDA grants emergency use clearance to Danaher Corp's COVID-19 antibody test; strategizing amid misinformation spread on the pandemic.

Rita E. Numerof, PhD, is the president of Numerof & Associates, a firm that helps businesses across the healthcare sector define and implement strategies for winning in dynamic markets. For more than 25 years, she has helped executives understand the implications of an evolving healthcare market. Working with leaders in the healthcare space, she has consulted with everyone from top academic and community hospital systems, payers, and Fortune 500 pharmaceutical, device, and diagnostics companies. She is the coauthor of several books, most recently, "Bringing Value to Healthcare: Practical Steps for Getting to a Market-Based Model" (2016).