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Acute myeloid leukemia is a complicated heterogenous hematological cancer with a poor prognosis, but novel targets may lead to improved treatment and outcomes going forward.

Previous studies have shown ruxolitinib effective in symptom relief and hematocrit control for hydroxyurea-resistant polycythemia vera, but its role in disease progression is not yet clear.

Michael Diaz, MD, president and managing physician, Florida Cancer Specialists & Research Institute, previews the Tampa meeting of The American Journal of Managed Care®'s Institute for Value-Based Medicine® (IVBM), cohosted by Florida Cancer Specialists & Research Institute.

Chronic kidney disease is the fastest-growing noncontagious disease in the United States. On this episode of Managed Care Cast, we speak with Mike Spigler, vice president of patient support and education for the American Kidney Fund, who is spearheading the Unknown Causes of Kidney Disease Project, which aims to help underserved patients get to the root cause of their kidney disease, while also helping to solve this mystery for a broader patient population.

Hilary Baldwin, MD, medical director, Acne Treatment and Research Center, explains the microencapsulation technology in Twyneo cream and what research went into its development.

The CDC said that 75% of children under age 17 and more than 60% of adults up to age 49 have evidence of prior infection with SARS-CoV-2, the virus that causes COVID-19.

A new study has found that sleep duration and consistency during the COVID-19 pandemic were potential risk factors for decreased mental wellness.

When clinicians consider the patient journey from beginning to end, they begin to understand how difficult it is for patients to access care, said Elaine Goodman, MD, MBA, clinical lead for population health management, Mass General Brigham.

With further research, a selection of combination therapies could increase patient response in various cancer types.

Melissa Johnson, MD, program director of Lung Cancer Research at Sarah Cannon, discusses the potential of certain drug classes for lung cancer.

There may be a small, but not overwhelming, benefit for certain individuals aged 40 to 59 years who have a slightly elevated risk of future cardiovascular disease (CVD) to start taking aspirin, according to an update released by the US Preventive Services Task Force (USPSTF).

Elevated prevalence of post-traumatic stress disorder seen in family members of patients with COVID-19 treated in intensive care units; 9 rare respiratory cancers linked with burn pit exposure among veterans; adenovirus suggested as potential cause of unexplained cases of pediatric hepatitis.

A simple score can identify the patients at risk of severe infection within 4 months of initiating treatment, highlighting candidates to be treated with prophylactic antibiotics.

A meta-analysis found that a third of patients with rheumatoid arthritis (RA) in a sample had metabolic syndrome, which can double the risk of cardiovascular outcomes in this population.

Recent studies suggest patients with Parkinson disease (PD) suffer from tooth grinding and related pain at higher rates than healthy controls.

Patients were younger and had more advanced disease at diagnosis, according to the study.

Clinicians should be vigilant and perform neurological and ophthalmological examinations in patients with persistent headaches, the authors said.

Gary Owens, MD, president of Gary Owens Associates, outlines the current epidemiological knowledge of pulmonary arterial hypertension (PAH).

More patients with atopic dermatitis achieved mild disease severity by 1 month of treatment with adjuvant dupilumab and tacrolimus vs dupilumab alone.

A multitrait model of corneal parameters was effective in identifying new keratoconus risk loci, resulting in enhanced polygenic risk score models.

The financial toxicity of newer metastatic breast cancer (MBC) treatments is a significant concern and requires stakeholders to work together to find the best value- and evidence-based treatments for patients, said Hatem Soliman, MD, medical director, Clinical Trials Office, Moffitt Cancer Center.

The US government is increasing access of Pfizer's COVID-19 antiviral pill to all pharmacies nationwide; stark hospitalization rates in unvaccinated children; a steady increase observed in US influenza cases and hospitalizations.

The findings suggest that the tool can be used to not only assess cognitive impairment in Huntington disease (HD) but also to detect brain atrophy patterns associated with cognitive status in these patients.

Inflammatory microenvironments appear to enhance melanoma cells’ ability to control T-cell responses.

Aldo-keto reductase 1C3 (AKR1C3) has been identified as a potential biomarker and target in several cancers, and a recent study found it to be a potential biomarker in T acute lymphoblastic leukemia/lymphoma (T-ALL).

The trends in the hemophilia treatment market are gaining momentum with increasing incidences of hemophilia A and B and staggering need for their treatments, including gene, anti-tissue factor pathway inhibitor, and factor replacement therapies.

A retrospective analysis found that patients with hidradenitis suppurativa had a high burden of disease despite active treatment by a dermatologist.

Patients with chronic rhinosinusitis (CRS) with nasal polyps identified several unmet needs regarding their condition, particularly a lack of public and physician awareness on disease burden and poor sleep quality.