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Findings from the single-arm, open-label ASCEND-Peds trial suggest olipudase alfa is well-tolerated and may lead to clinically meaningful improvements in patients with acid sphingomyelinase deficiency (ASMD) who do not have neurovisceral manifestations.

Authors from the University of Colorado say factors from skin irritations, to cost, to lack of insurance coverage, to physician barriers have limited uptake of automated insulin delivery systems.

Multidisciplinary care that includes growth hormone treatment should not cease once patients with Prader-Willi syndrome reach adulthood, according to authors of a study on care outcomes.

New data show the prevalence of potential drug-drug interactions varies according to the drug use pattern considered, with people living with HIV using multiple illegal drugs being at the highest risk.

Mild cognitive impairment has been proposed as a marker for the prodromal phase of Parkinson disease (PD), but little is known about its presentation in community-dwelling older adults.

Circulating Interleukin-11 is difficult to detect in healthy individuals, but when it is present in various inflammatory diseases, it has an elevated present in affected tissues, according to a literature review.

Misinformation about flu vaccines must be dealt with immediately, according to Leslie Kantor, PhD, MPH, chair and professor of the Department of Urban-Global Public Health, Rutgers School of Public Health.

Authors of a review published in Hormones outlined the benefits of healthy eating and physical activity to prevent and improve non-alcoholic fatty liver disease.

According to the researchers, the case study suggests that better results are achieved when using cytoreductive treatment and low-dose aspirin.

A high comorbidity burden, including psychiatric, autoimmune, and systemic conditions, was found in US adult ambulatory populations with atopic dermatitis.

In a small study, researchers identified high nasal-paranasal sinus nitric oxide and carbon monoxide levels as potential migraine biomarkers.

New data suggest more children are being diagnosed with autism in the United States; Biden pushes for coverage of at-home COVID-19 tests; different pollutants may affect the ratio of boys to girls born.

A small study found that patients with chronic cough saw improvements in symptoms following transcutaneous electrical nerve stimulation treatment, with minimal adverse effects.

Michael Thorpy, MD, director, Sleep-Wake Disorders Center, Montefiore Medical Center, and professor of neurology, Albert Einstein College of Medicine, speaks on the common occurrence of other comorbidities in patients with chronic insomnia.

Robert J. Hopkin, MD, clinical geneticist, Cincinnati Children's Hospital Medical Center, addresses major unmet needs in Fabry disease, ranging from uncontrolled pain to irreversible damage prior to treatment initiation.

Patients with concomitant psoriasis and psoriatic arthritis (PsA) were shown to be 3.1-fold more likely to achieve complete skin clearance when treated with brodalumab vs ustekinumab after 52 weeks, with further improvements reported for quality of life (QOL).

Testing for spinal muscular atrophy in an Australian newborn screening program identified patients across socioeconomic and cultural demographics, mitigating inequity and providing patients with access to multidisciplinary treatment.

A systematic review showed that a high fractional exhaled nitric oxide (FeNO) value before starting inhaled corticosteroid (ICS) therapy may be associated with higher response rates in patients with chronic cough.

Victoria Ly, MD, MPH, outlines one method of tackling vision screening follow-up rate disparities among children in Arkansas.

Processes used to identify and understand genetic markers detailing the prognosis and responsiveness to therapy in adrenocortical carcinoma (ACC) face a number of implementation barriers, limiting the potential for individualized ACC management.

In a local market with multiple accountable care organizations and multiple Medicare Advantage plans, how do we administratively set rates that are localized enough so that they do not drive consolidation?

Next-generation sequencing uncovered 3 subtypes of epidermal growth factor receptor–mutant stage 2 and 3 non–small cell lung cancer (NSCLC) that predicted patient outcomes to adjuvant therapy.

The first case of the Omicron COVID-19 variant has been detected in the United States; Supreme Court justices signal support for upholding Mississippi’s abortion law; a federal judge blocks the Biden administration’s vaccine mandate for health care workers.

Adriaan Voors, MD, discusses possible mechanisms of action of empagliflozin that produce such beneficial results among patients with heart failure, in an interview about the EMPULSE trial prior to this year’s American Heart Association Scientific Sessions.

A tool utilizing 5 predictors was found to be reliable at identifying patients at a high risk of cardiovascular disease who were also at risk of developing chronic kidney disease (CKD), potentially allowing providers to implement prevention strategies sooner than ever before.

The trend was true when investigators used body mass index to classify weight, and when measures such as relative body mass index and percentage of body fat were used.

This new study from Finland highlights both the potential for severe psychiatric disturbances among women with polycystic ovary syndrome (PCOS) and lack of extensive knowledge of the toll of psychoses among this group.

More than 1 in 3 patients with atopic dermatitis reported incidence of dupilumab-induced ocular surface disease (DIOSD), with asthma and family history of AD shown to further increase the risk of developing DIOSD.